Yoga program to improve function in people with knee osteoarthritis
Effects of a Yoga Program on the Functionality of Individuals With Knee Osteoarthritis
This trial will try a structured yoga program to see if it improves function in people aged 45 and older who have knee osteoarthritis compared with standard therapeutic exercise.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 40 Years to 80 Years |
| Sex | All |
| Sponsor | University of Nove de Julho Academic / other |
| Locations | 1 site (São Paulo) |
| Trial ID | NCT07006883 on ClinicalTrials.gov |
What this trial studies
This is a randomized, concealed-allocation interventional comparison of a structured yoga program versus a conventional therapeutic exercise program for people with knee osteoarthritis. About 90 participants (approximately 45 per group) aged 45 years or older with a clinical diagnosis of knee osteoarthritis will be enrolled and undergo baseline assessments before randomization. Participants will be allocated 1:1 to either the yoga intervention or the therapeutic exercise control and will complete the assigned exercise program with follow-up functional assessments. The primary focus is on change in functionality, with eligibility limited to Kellgren–Lawrence grade 1–3 and exclusion of conditions that would preclude safe exercise.
Who should consider this trial
Good fit: Ideal candidates are adults aged 45 or older with a clinical diagnosis of knee osteoarthritis (symptoms >3 months, morning stiffness <30 minutes) and radiographic grade 1–3 who can safely perform exercise.
Not a fit: Patients with severe osteoporosis, active inflammatory arthritis, recent joint replacement, major neurologic or cardiopulmonary impairments, bilateral hip or knee disease, or other listed exclusions are unlikely to be eligible or benefit from this program.
Why it matters
Potential benefit: If successful, the yoga program could offer a non-drug option to improve mobility and daily function for people with knee osteoarthritis.
How similar studies have performed: Some small trials and pilot studies of yoga and mind-body exercise for osteoarthritis and chronic musculoskeletal pain have shown promising but mixed results, so evidence specific to knee osteoarthritis remains limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * A clinical diagnosis of knee osteoarthritis (knee pain for \> 3 months) * Morning stiffness \<30 minutes * Crepitus * Bone tenderness, and absence of palpable heat and/or diagnosis established radiographically (determined by Kellgren and Lawrence grade 1 to 3 on a scale 1 up to 4) Exclusion Criteria: * Bilateral hip or KOA * Severe osteoporosis * Fibromyalgia * Clinical history of tumors or cancer * Active inflammatory joint diseases (rheumatoid arthritis, gout), undergoing any joint replacement of the lower extremity * Neurological diseases (Parkinson's disease, Stroke, Multiple Sclerosis, muscular dystrophies, neuromotor disease, Alzheimer's disease) * Infected wounds or osteomyelitis in the knee region * Deep vein thrombosis or thrombophlebitis, sensory changes in the lower limbs * A cognitive and cardiopulmonary impairment that may prevent or limit the performance of exercises * Use of a walking assistance device, history of recent trauma to the knee * Be performing or having prior any form of treatment involving physiotherapy, intra-articular corticosteroids, anti-inflammatories, opioid medication, or chondroprotective in the six months before the start of interventions
Where this trial is running
São Paulo
- University of Nove de Julho — São Paulo, Brazil (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.