Lysyl Enzymes in Knee Osteoarthritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will measure serum levels of lysyl hydroxylase, lysyl oxidase, and related LOX family enzymes in adults with knee OA at different stages and compare them to healthy controls. It will focus on how these enzymes relate to joint degeneration and ECM cross-linking in the cartilage. Participants are female, 40–70 years old, with knee OA, recruited from Afyonkarahisar Health Sciences University, with BMI 18.5–40 kg/m². The study will exclude those with major comorbidities or inflammatory rheumatic diseases. No interventions are administered; samples and data are collected to explore potential biomarkers and disease mechanisms.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Female participants aged between 40 and 70 years.
* Diagnosed with knee osteoarthritis according to clinical and radiographic criteria, and presenting to the Department of Physical Medicine and Rehabilitation, Afyonkarahisar Health Sciences University (AFSU).
* Body Mass Index (BMI) between 18.5 and 40 kg/m².

Exclusion Criteria:

* Presence of metabolic diseases or severe comorbidities, including uncontrolled diabetes mellitus, chronic kidney disease (GFR \< 60 mL/min/1.73 m²), liver failure, malignancy, severe cardiovascular disease, chronic respiratory disorders, or chronic intestinal diseases.
* Any inflammatory arthritis or other rheumatologic disease with related signs or symptoms.
* History of knee trauma involving cruciate ligaments or menisci within the past 3 months.
* Secondary osteoarthritis due to other joint disorders such as septic arthritis, avascular necrosis, or Paget's disease.
* History of previous knee surgery.
* Recent intra-articular injection to the knee joint within the last 3 months.

Where it's running

• Afyonkarahisar Health Sciences University, Department of Physical Medicine and Rehabilitation
  Afyonkarahisar, Turkey (Türkiye) Recruiting

Study contacts

• Principal investigator: Hasan Toktaş, Professor — Afyonkarahisar Health Sciences University
• Study coordinator: Hasan Toktaş, Professor
• Email: hasantoktas@yahoo.com
• Phone: +905052212901

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.