What factors predict bite changes when using a mandibular advancement device for sleep apnea

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study examines how masticatory muscle activity, measured with surface electromyography, relates to occlusal changes after six months of mandibular advancement device therapy in adults with obstructive sleep apnea. Data are collected before and during MAD treatment, including imaging, EMG, sleep testing, and questionnaires, to identify electrophysiological profiles linked to dental displacement. The goal is to define patient-specific profiles that could guide personalized care and reduce treatment dropouts due to adverse bite changes. The study is conducted at Toulouse University Hospital, leveraging standard pre-treatment imaging and follow-up assessments. Findings may inform risk stratification and optimization of MAD therapy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient with complete dentition (up to second molars)
* Polysomnography or polygraphy
* Diagnosis of OSA
* Patient receiving OAM treatment at the Odontology Department of Toulouse University Hospital
* Patient with contemporary panoramic and lateral cephalometric X-rays (common practice) taken at the time of orthotic treatment
* Individual affiliated with or covered by a social security scheme
* Voluntary, informed, written consent, signed by both participant and investigator (prior to inclusion and any necessary research-related examinations).

Exclusion Criteria:

* Inability to provide informed consent
* Pregnant or breastfeeding patient
* Patient with curators, guardians, or legal protection

Where it's running

• University Hospital of Toulouse
  Toulouse, France Recruiting

Study contacts

• Principal investigator: Constance CUNY, MD — University Hospital, Toulouse
• Study coordinator: Constance CUNY, MD
• Email: cuny.c@chut-toulouse.fr
• Phone: +33615282467

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Examining brain activity in patients with obstructive sleep apnea

  This study is testing how the brains of people with obstructive sleep apnea react to breathing challenges while they are awake to see if it affects their thinking skills.

  Recruiting CHU de Reims · Reims · NCT05147649

• Topical lavender oil to help recovery after lung resection

  This study tests whether applying lavender essential oil to the skin around the surgical wound for three days after lung surgery can improve recovery and reduce pain.

  Recruiting University Hospital, Toulouse · Toulouse · NCT07622602

• Does THC-COOH appear in sweat after a child’s cannabis intoxication?

  This study tests whether the cannabis metabolite THC-COOH can be found in sweat after a young child’s cannabis intoxication to see if hair testing is reliable for prior exposure.

  Recruiting University Hospital, Toulouse · Toulouse · NCT07524088

• Intensive rhythm-based dance program to improve learning skills in children with cerebral palsy

  This project will try a rhythm-based intensive dance program to see if it helps children aged 6–17 with cerebral palsy improve motor learning and related skills.

  Recruiting University Hospital, Toulouse · Toulouse, Occitanie · NCT07500896

• Home-use Grasp Neuroprosthesis for helping with finger opening after stroke

  This study tests a wearable grasp neuroprosthesis at home to see if it helps people who have trouble opening their hand after a stroke.

  Recruiting at 2 sites University Hospital, Toulouse · Toulouse and 1 other locations · NCT07500480

• [18F]-DPA-714 PET to detect brain inflammation in autoimmune encephalitis

  This test tries to see if [18F]-DPA-714 PET scans can detect brain inflammation in adults newly diagnosed with autoimmune encephalitis.

  Recruiting Phase 2 University Hospital, Toulouse · Toulouse · NCT07488117

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.