Examining brain activity in patients with obstructive sleep apnea
Official title: Functional Magnetic Resonance Imaging in Patients With Obstructive Sleep Apnea Syndrome, With and Without CPAP, During Wakefulness - Impact on Cognitive Functions
Run by CHU de Reims · NCT05147649 · Data updated 2026-11-12
This study is testing how the brains of people with obstructive sleep apnea react to breathing challenges while they are awake to see if it affects their thinking skills.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 70 (estimated) |
| Sponsor | CHU de Reims Academic / other |
| Locations | 1 site (Reims) |
| Status | Recruiting |
| Started | March 2, 2023 |
| Main results expected | January 2, 2027 |
| Study ends | July 2, 2027 |
| Registry record updated | December 2, 2025 |
| Trial ID | NCT05147649 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults with severe obstructive sleep apnea (AHI > 30/h) who are not currently receiving CPAP treatment.
✕Probably not a fit
Patients with other sleep disorders, neurological or respiratory pathologies, or those who cannot undergo MRI will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the brain's cortical activity in patients with obstructive sleep apnea syndrome (OSAS) while they are awake. It aims to determine if these patients exhibit similar respiratory-related cortical responses as normal subjects when subjected to inspiratory loading. Additionally, the study will analyze whether these cortical compensatory mechanisms have any cognitive consequences. The intervention involves the use of functional magnetic resonance imaging (fMRI) to observe brain activity patterns.
Why it matters
Potential benefit: If successful, this study could enhance understanding of the cognitive impacts of obstructive sleep apnea and lead to improved treatment strategies.
How similar studies have gone: While similar studies have explored brain activity in sleep apnea, this specific approach using fMRI in awake patients is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria : 1. OSAS patients * severe OSAS with an Apnea-Hypopnea Index (AHI) \> 30/h * without CPAP treatment 2. Non-OSAS patients * absence of OSAS (AHI \< 15/h and absence of excessive daytime sleepiness with Epworth score \<11) Non-inclusion criteria : * \< 18 years old * \>75 years old * left-handed * BMI\> 40 kg/m² * another sleep disorder * central component of sleep apnea syndrome (central apnea index\> 5 / h) * current or past neurological pathology * respiratory pathology (obstructive ventilatory disorder, restrictive ventilatory disorder, hypercapnia) * MRI contraindication (metallic foreign body, claustrophobia, pregnant woman, etc.) * taking drugs that can modify the BOLD signal on MRI (psychotropic drugs, vasodilators, vasoconstrictors, etc.), * uncorrected sensory impairment (vision or hearing) * protected by law. Exclusion criteria : * pregnant woman according to the positive beta-hCG test result * left-handed following the laterality questionnaire * MINI results showing: * a current mood episode * a current disorder of the use of psychoactive substances or in the last 6 months (excluding tobacco) * an eating disorder * a diagnosis of bipolar disorder, current or past schizophrenia
Where it's running
-
Chu Reims
Reims, France Recruiting
Study contacts
- Study coordinator: Claire Launois
- Email: claunois@chu-reims.fr
- Phone: 3 26 78 83 70
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.