Weight-loss with exercise and diet in adults with type 2 diabetes and CKD

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study enrolls 60 sedentary adults aged 36–58 with stage 3–4 CKD and type 2 diabetes, BMI 30–35 kg/m². Participants are randomized to receive a 12-week program of supervised aerobic treadmill training plus a 1200 kcal/day diet or standard nephrology care without lifestyle changes. Biomarkers such as TNF-α, IL-6, sCRP, CD, MDA, GSH, GPx, and SOD are measured at baseline and after 12 weeks to assess the biological impact of the lifestyle intervention. The trial aims to determine if lifestyle modification can modulate inflammatory and oxidative stress pathways in this high-risk population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* sedentary lifestyle for at least three months prior to enrollment
* body mass index (BMI) of 30-35 kg/m².

Exclusion Criteria:

* using tobacco
* heart failure
* coronary arteries
* severe heart valve problems
* pregnant
* liver inflammation
* kidney transplant
* physical injuries restricting them from exercising
* utilization of anti-inflammatory medications

Where it's running

• Mona Mohamed Abdelkhalek
  Cairo, Egypt Recruiting

Study contacts

• Principal investigator: Mona Mohamed Abdelkhalek — Badr University
• Study coordinator: Mona Mohamed Abdelkhalek, assistance professor
• Email: 3m.sons@gmail.com
• Phone: 00201024056108

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.