Examining how metabolism relates to body composition and size

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the relationships between resting energy expenditure, body composition, and body surface area in both healthy individuals and those with metabolic disorders. Participants, aged 2 years and older, will spend two days and one night in the hospital, where they will provide medical histories and answer questions about their lifestyle and dietary habits. The study will compare traditional methods of estimating body surface area with more accurate measurements to better understand metabolism across different populations.

Why it matters

Who can join: the full rules

* INCLUSION CRITERIA:

In order to be eligible to participate in this study, an individual must meet all the following criteria for their cohort:

Cohort 1 - Healthy Volunteers

* Male or female, aged \>=2 years
* In good general health as evidenced by medical history

Cohort 2 - Patients

* Male or female, aged \>=2 years
* Diagnosed with diseases thought to alter metabolism or body composition (such as weight loss or gain, diabetes, renal disease, obesity, cancer, etc.) or taking medications thought to alter metabolism or body composition.

EXCLUSION CRITERIA:

An individual who meets any of the following criteria will be excluded from participation in this study:

* Participants over 200 kg due to the weight limit of the equipment.
* Presence of any implanted device that would interfere with measurements.
* Any moderate to severe limitations in mobility that would impede participation
* Hemoglobin less than 10 g/dL (in participants who would have blood drawn for research purposes).
* Participants with dietary allergies, intolerances or eating patterns that would preclude them from consuming metabolic meals.
* Participants unwilling or unable to give informed consent.
* Participants with any other significant physical, medical, or psychiatric limitations, illness or conditions that may preclude them from completing the majority of the tests in this study per the discretion of the PI.

Where it's running

• National Institutes of Health Clinical Center
  Bethesda, Maryland, United States Recruiting

Study contacts

• Principal investigator: Kong Y Chen, Ph.D. — National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Study coordinator: Margaret S McGehee, C.R.N.P.
• Email: mcgeheems@mail.nih.gov
• Phone: (301) 594-6799

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Weight-loss with exercise and diet in adults with type 2 diabetes and CKD

  This study tests whether a 12-week supervised aerobic exercise program plus a calorie‑restricted diet can change inflammatory and oxidative stress biomarkers in overweight adults with type 2 diabetes and moderate chronic kidney disease.

  Recruiting Badr University · Cairo · NCT07657286

• CKD Awareness, Referrals, Education, and Support for Early-Stage CKD in Adults with Diabetes

  This intervention tests whether education, motivational support, and social backing delivered virtually can help adults with diabetes and early CKD slow kidney decline and stay engaged with care.

  Recruiting University of Illinois Chicago · Chicago, Illinois · NCT07210710

• Observational register of adults with diabetes and endocrine/metabolic disorders

  This study will collect medical information from adults with diabetes or related metabolic and endocrine conditions to see how markers relate to disease severity and progression.

  Recruiting IRCCS San Raffaele · Milan, Italy · NCT07206875

• Health checks for diabetes, blood pressure, and kidney health in Indigenous communities.

  This study is testing health checks for diabetes, blood pressure, and kidney health in Indigenous communities to see if it can help identify people at risk for kidney disease and improve their care.

  Recruiting at 2 sites University of Manitoba · Calgary, Alberta and 2 other locations · NCT03595267

• Observational look at how Kremezin works in adults with advanced chronic kidney disease

  This study tests whether Kremezin helps adults with advanced kidney disease when used as part of routine care, by tracking safety and kidney function over up to 48 weeks.

  Recruiting HK inno.N Corporation · Seoul · NCT07930169

• Kidney and Heart Health in Adults with Type 2 Diabetes and CKD Treated with Semaglutide in China

  This study tests whether semaglutide injections help kidney and heart health in adults with type 2 diabetes and chronic kidney disease.

  Recruiting Phase 4 Novo Nordisk A/S · Fuyang, Anhui and 25 other locations · NCT07900438

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.