Vonoprazan to prevent ulcers after endoscopic variceal band ligation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized, placebo-controlled Phase 2 trial enrolling adults with confirmed liver cirrhosis who require endoscopic variceal band ligation (EVBL). Participants are assigned to receive vonoprazan 20 mg once daily or a matching placebo for 14 days after EVBL, with a follow-up endoscopy about two weeks later to check for ulcers. Outcomes include the number and severity of post-EVBL ulcers, patient-reported swallowing pain or chest discomfort, and safety/tolerability in patients with cirrhosis. The trial aims to determine if acid suppression with vonoprazan improves comfort and reduces complications after the procedure.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18 to 75 years (male or female)
* Diagnosis of liver cirrhosis confirmed by clinical, biochemical, or imaging findings.
* Presence of documented esophageal varices requiring endoscopic variceal band ligation (EVBL).
* Able and willing to provide written informed consent in English or Urdu.
* Willing to comply with study procedures, including taking study medication and attending follow-up endoscopy.

Exclusion Criteria:

* History of gastric or esophageal surgery
* Allergy or contraindication to vonoprazan or study drug components
* Pregnant or lactating women
* Individuals who are non-cooperative or unable to understand local languages
* Critically ill patients, including:

ICU admission Requirement for mechanical ventilation GCS \< 10

* Active gastrointestinal bleeding at the time of enrollment
* Malignancy of the upper gastrointestinal tract

Where it's running

• King Edward Medical University/Mayo Hospital
  Lahore, Punjab Province, Pakistan Recruiting

Study contacts

• Study coordinator: Muhammad R Tariq, MBBS,FCPS
• Email: ibneislam190@gmail.com
• Phone: +923337692728

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.