Vitamin D3 before dental implants to help bone healing
Official title: Efficacy of Perioperative Oral Vitamin D3 Supplementation on Implant Osseointegration in Patients With Vitamin D Deficiency
Run by Nantes University Hospital · NCT06776640 · Data updated 2026-11-12
This pilot looks at whether taking vitamin D3 for six months helps implant bone integration in adults with vitamin D deficiency who are getting dental implants.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Nantes University Hospital Academic / other |
| Locations | 1 site (Nantes, Nantes) |
| Status | Recruiting |
| Started | January 15, 2025 |
| Main results expected | January 15, 2027 |
| Study ends | May 15, 2027 |
| Registry record updated | June 24, 2026 |
| Trial ID | NCT06776640 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 or older with vitamin D deficiency or insufficiency who are candidates for dental implants at Nantes University Hospital.
✕Probably not a fit
Patients without vitamin D deficiency or those who do not respond to supplementation may not see a benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational pilot study evaluates whether pre- and perioperative vitamin D3 supplementation can influence osseointegration in patients with vitamin D deficiency undergoing dental implant placement at Nantes University Hospital. Data will be collected from about three months before surgery through three months after, focusing on imaging and clinical outcomes related to implant integration. Participants are adults with vitamin D deficiency or insufficiency who consent and meet local eligibility criteria. The study will compare participants who receive supplementation with those who have not been screened for vitamin D, within the same clinical setting. No interventional randomization is described, and results will suggest whether vitamin D3 may support osseointegration in this population.
Why it matters
Potential benefit: If successful, vitamin D3 supplementation could improve dental implant stability and healing in people with vitamin D deficiency.
How similar studies have gone: Previous research has suggested vitamin D can influence bone healing, but this specific perioperative approach in implantology is exploratory.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male or female patient ≥ 18 years old, candidate for dental implant placement. * with vitamin D deficiency or insufficiency: 25(OH)D \< 25 ng/L. * affiliated with a social security scheme. Exclusion Criteria: * with a local contraindication for implant placement. * under guardianship, curatorship, or legal protection * Pregnant or breastfeeding women
Where it's running
-
CHU Nantes-Department of Dentistry
Nantes, Nantes, France Recruiting
Study contacts
- Principal investigator: Anne-Gaelle Chaux, MD PhD — Nantes University Hospital
- Study coordinator: Anne-Gaelle Chaux, MD PhD
- Email: annegaelle.chaux@chu-nantes.fr
- Phone: 02 53 48 28 35
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Examining gum changes after removing an implant crown
This study is testing how the gums change after taking off an implant crown to see how long it takes for those changes to happen, which is important for making new crowns look good.
-
Using UVC to enhance dental implant stability
This study tests if using UVC light on dental implants can help them bond better with the bone and allow for quicker use after surgery.
-
Using static magnetic fields to improve dental implant stability
This study is testing if using magnets can help dental implants bond better with the jawbone in patients who have no teeth.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.