Vitamin D supplementation for patients with depression
Follow-up Study With Randomized Clinical Vitamin D Supplementation Trial on Patients With Depression (DepFuD)
This study is testing whether taking vitamin D for six months can help adults with depression feel better and improve their overall recovery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 3028 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Kuopio University Hospital Academic / other |
| Locations | 1 site (Kuopio) |
| Trial ID | NCT02521012 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of a six-month vitamin D supplementation on patients with non-psychotic, unipolar depression. It aims to clarify how vitamin D levels influence treatment response and recovery, while also exploring biological pathways related to depression. The trial will involve a double-blinded randomized controlled design, recruiting 3028 patients aged 18-65 who are seeking treatment for depression. The study will also examine bio-psychosocial factors that may contribute to recovery and working ability in these patients.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-65 with mild to severe non-psychotic unipolar depression seeking treatment.
Not a fit: Patients with bipolar disorder, psychotic depression, or other conditions affecting vitamin D metabolism may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a novel treatment option for improving outcomes in patients with depression.
How similar studies have performed: Previous studies have suggested a positive correlation between vitamin D levels and treatment outcomes in depression, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients referred to the recruitment sites for treatment for depression * mild, moderate or severe depression, * mild, moderate or severe episode of recurrent depression Exclusion Criteria: * bipolar or psychotic depression * psychotic disorder * severe substance abuse * disabilities in senses that affect functioning and severely threat completing the trial * diseases that affect vitamin D metabolism (such as sarcoidosis, hypercalcemia, hypofunction of kidney) * pregnancy or lactation * current use of high dose vitamin D supplementation * current use of high dose calcium supplementation
Where this trial is running
Kuopio
- Kuopio University Hospital, Department of Psychiatry — Kuopio, Finland (Recruiting)
Study contacts
- Study coordinator: Heimo Viinamäki, Professor
- Email: heimo.viinamaki@kuh.fi
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.