Vietnamese children with movement disorders of unknown cause: a patient registry
Official title: Phenotypic and Genotypic Characterization of Pediatric Movement Disorders of Unknown Etiology in Vietnam
Run by University of Medicine and Pharmacy at Ho Chi Minh City · NCT07695610 · Data updated 2026-11-12
This registry collects clinical and genetic data from Vietnamese children with movement disorders where a cause isn’t yet known to see how genetics might explain their symptoms.
Quick facts
| Study type | Observational |
|---|---|
| Ages | Any age to 18 Years |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | University of Medicine and Pharmacy at Ho Chi Minh City Academic / other |
| Locations | 2 sites (Ho Chi Minh City, Ho Chi Minh City and 1 other locations) |
| Status | Recruiting |
| Started | April 17, 2026 |
| Main results expected | February 1, 2028 |
| Study ends | January 31, 2029 |
| Registry record updated | July 10, 2026 |
| Trial ID | NCT07695610 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Children under 18 with clinically confirmed movement disorders of unknown etiology after standard evaluation, treated or evaluated at the participating centers, and whose guardians consent to genetic testing.
✕Probably not a fit
Participants with clearly identifiable non-genetic causes or those whose genetic testing does not yield actionable information may not benefit directly.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective observational registry gathers standardized clinical data, neuroimaging and laboratory results, and video recordings (with consent) from Vietnamese children with movement disorders of unknown etiology. Blood samples are analyzed by whole-exome sequencing to identify genetic variants and correlate them with phenotypes. Participants are evaluated by pediatric neurology specialists to confirm movement phenotypes and exclude acquired causes, with data used to improve understanding, counseling, and potential diagnostic pathways. The study is conducted at major pediatric centers in Ho Chi Minh City and aims to map the clinical and genetic spectrum of these disorders in Vietnam.
Why it matters
Potential benefit: Genetic findings may improve diagnostic clarity and inform counseling, prognosis, and follow-up for affected children and their families.
How similar studies have gone: Similar genetic registries and exome sequencing efforts in pediatric movement disorders have yielded diagnostic insights, though population-specific data for Vietnam are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Children younger than 18 years old. * Patients with clinically confirmed movement disorders based on direct examination and/or video review by at least two pediatric neurology specialists. * Patients with movement disorders of unknown etiology after appropriate neurological evaluation and exclusion of clear acquired causes. * Patients evaluated or treated at University Medical Center Ho Chi Minh City or Children's Hospital 1 during the study period. * Patients and/or legal guardians who provide written informed consent for study participation and genetic testing. Exclusion Criteria: * Patients with isolated or transient primary tic disorders. * Patients with a confirmed acquired cause of movement disorder. * Patients or legal guardians who decline participation or withdraw from the study. * Patients with insufficient clinical information or unavailable biological samples for genetic analysis.
Where it's running
-
Children's Hospital 1, Ho Chi Minh City
Ho Chi Minh City, Ho Chi Minh City, Vietnam Recruiting -
University Medical Center Ho Chi Minh City
Ho Chi Minh City, Ho Chi Minh City, Vietnam Recruiting
Study contacts
- Principal investigator: Linh B. Y Nguyen, MD, MSc, PHD Candidate — University of Medicine and Pharmacy at Ho Chi Minh City
- Study coordinator: Bich Y L Nguyen, MD, MSc, PhD Candidate
- Email: nbylinh.ncs25@ump.edu.vn
- Phone: +84 939077089
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.