VEXUS ultrasound to predict acute kidney injury in severe preeclampsia

Accuracy of the Venous Excess Ultrasound Score at Hospital Admission to Predict Acute Kidney Injury in Preeclampsia With Severe Features: A Prospective Observational Study

This project will test whether the venous excess ultrasound (VEXUS) score taken at hospital admission can predict acute kidney injury in people with severe preeclampsia.

Quick facts

• Study type: Observational
• Enrollment: 40 (estimated)
• Ages: 20 Years to 40 Years
• Sex: Female
• Sponsor: Cairo University (other)
• Locations: 1 site (Cairo, Giza Governorate)
• Trial ID: NCT07040696 on ClinicalTrials.gov

What this trial studies

This is an observational study that records the venous excess ultrasound (VEXUS) score at hospital admission in patients with preeclampsia with severe features and follows them for development of acute kidney injury. Investigators will obtain Doppler ultrasound views to calculate the VEXUS score and compare admission scores to subsequent kidney outcomes. Key exclusions include preexisting renal impairment, prior renal replacement therapy or transplantation, and inability to obtain adequate Doppler views. The study is single-center at Cairo University and uses routine clinical monitoring to identify AKI events.

Who should consider this trial

Good fit: People admitted with preeclampsia with severe features who have baseline serum creatinine ≤ 1.3 mg/dL and can undergo adequate Doppler imaging are the intended participants.

Not a fit: Patients with preexisting renal impairment, prior need for renal replacement therapy or renal transplantation, known peripheral vascular disease, or those in whom adequate Doppler views cannot be obtained are unlikely to benefit from this approach.

Why it matters

Potential benefit: If successful, this could help clinicians identify people with severe preeclampsia who are at higher risk of acute kidney injury so they can monitor and treat them earlier.

How similar studies have performed: VEXUS and other venous congestion ultrasound approaches have shown promise correlating venous congestion with AKI in critical care settings, but application specifically in preeclampsia is novel and data are limited.

Eligibility criteria

Inclusion Criteria:

* preeclampsia with severe features

Exclusion Criteria:

* Patient refusal
* Preexisting renal impairment (defined as baseline serum creatinine \> 1.3 mg/dl)
* Inability to obtain adequate Doppler views
* Renal transplantation
* Previous need for renal replacement therapy
* Known peripheral vascular disease

Where this trial is running

Cairo, Giza Governorate

• Cairo University — Cairo, Giza Governorate, Egypt (RECRUITING)

Study contacts

• Study coordinator: cairo university

Conditions: Preeclampsia, Acute Kidney Injury, preeclampsia, VEXUS score, AKI