Venous congestion and thinking problems after heart surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adult patients undergoing elective midline thoracic cardiac surgery will have clinical, hemodynamic, laboratory, and cognitive data collected before, during, and after the operation. Intraoperative monitoring including transesophageal echocardiography and standard hemodynamic measurements will be used to characterize venous congestion. Cognitive function will be measured with preoperative and serial postoperative tests (including MMSE and POCD assessments) to track changes over time. Demographics, comorbidities, and surgery-related parameters will be recorded to correlate with venous congestion markers and cognitive outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients scheduled to undergo elective cardiac surgery via a midline thoracic incision;
2. ≥18 years;
3. A preoperative MMSE score\>23, without consciousness or language barriers, capable of cooperating with neurological examinations, cognitive function tests, and other assessments of neurological function.

Exclusion Criteria:

1. Contraindications for TEE;
2. Emergency cardiac surgery;
3. Major vascular surgery;
4. Redo cardiac surgery;
5. Severe infection requiring continuous antibiotic therapy;
6. Severe preoperative heart failure with left ventricular ejection fraction \< 30%;
7. A critical preoperative state (mechanical circulatory support, extracorporeal membrane oxygenation, current renal replacement therapy, mechanical ventilation, or cardiac arrest necessitating resuscitation);
8. Multi-organ dysfunction;
9. Known conditions that may interfere with the assessment or interpretation of hepatic vein, portal vein blood flow (such as liver cirrhosis or portal vein thrombosis) or the renal vein blood flow (such as urinary tract obstruction);
10. Planned cardiac transplantation or ventricular assist device implantation;
11. Pregnancy;
12. Insufficient ultrasonographic imaging;
13. Restarting CPB after first CPB cessation during surgery;
14. Requirement for cardiac assist devices (ECMO, IABP, or ventricular assist device) after CPB intraoperatively;
15. Neurological or psychiatric diagnoses that may affect cognitive performance or cognitive testing;
16. Documented delirium before surgery

Where it's running

• The Department of Anesthesiology, The Affiliated Hospital of Yangzhou University, Yangzhou University
  Yangzhou, Jiangsu, China Recruiting

Study contacts

• Study coordinator: Zhuan Zhang, MD
• Email: zhangzhuancg@163.com
• Phone: +8615062791355

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.