Vascular graft and endograft infections: outcomes and immune responses
Official title: Analysis of Clinical Outcomes and Host Immune Response to Vascular Graft and Endograft Infections
Run by Aarhus University Hospital · NCT07696884 · Data updated 2026-11-12
This study tests how patients with suspected or diagnosed vascular graft or endograft infections, along with people getting planned implants and healthy donors, respond over time and what markers help diagnose infections.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Aarhus University Hospital Academic / other |
| Locations | 1 site (Aarhus) |
| Status | Recruiting |
| Started | May 17, 2024 |
| Main results expected | September 1, 2033 |
| Study ends | September 1, 2033 |
| Registry record updated | July 10, 2026 |
| Trial ID | NCT07696884 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 years and older with suspected or diagnosed central vascular graft or endograft infection, or individuals scheduled for elective central vascular graft or endograft implantation, plus healthy blood donors without active disease.
✕Probably not a fit
Patients with infections or planned implants outside the defined criteria or those unable to provide informed consent may not benefit from study findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective observational cohort and biobank study at Aarhus University Hospital examining central vascular graft and endograft infections. The study collects longitudinal clinical data and biospecimens from three groups: patients with infection, patients undergoing elective implantation, and healthy blood donors. It aims to characterize clinical outcomes, host immune responses, inflammatory biomarkers, pathogen-related factors, and explore novel microbiological methods such as microbial cell-free DNA sequencing. No interventional treatment is mandated; observational data and biospecimens will support biomarker discovery and diagnostic method development. The study includes collaborating centers in the Central Denmark Region to enhance generalizability within the region.
Why it matters
Potential benefit: If successful, findings could improve understanding of immune responses and biomarkers in vascular infections and advance diagnostic approaches.
How similar studies have gone: Previous observational studies in related infections have contributed to biomarker discovery, but this specific approach with prospective biobanking in vascular graft infections is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 years or older. * Able and willing to provide informed consent. * For the vascular graft or endograft infection group: suspected or diagnosed vascular graft or endograft infection in a central vascular prosthesis as determined by the treating clinicians. * For the elective vascular graft or endograft control group: planned central vascular graft or endograft implantation. * For the healthy blood donor control group: active blood donor registered at Aarhus University Hospital Blood Bank. * For the healthy blood donor control group: no current infection or other active disease. Exclusion Criteria: * For the elective vascular graft or endograft control group: surgery performed as an emergency procedure within 24 hours. * For the elective vascular graft or endograft control group: reoperation of a previously implanted vascular graft or endograft. * For the elective vascular graft or endograft control group: evidence suggestive of ongoing infection in the area of surgery. * Unable to provide informed consent.
Where it's running
-
Aarhus University Hospital
Aarhus, Denmark Recruiting
Study contacts
- Study coordinator: Rasmus A Nielsen, MD
- Email: raalni@rm.dk
- Phone: +4522897999
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.