Validation of a program to reduce dementia risk
Validation of a Multidomain Neuropsychological Intervention for Individuals at Risk of Dementia: the REMINDER Program
NA · University of Coimbra · NCT05296980
This study is testing a new program called REMINDER to see if it can help older adults at risk of dementia improve their thinking skills and reduce their chances of developing Alzheimer's disease.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 400 (estimated) |
| Ages | 60 Years to 75 Years |
| Sex | All |
| Sponsor | University of Coimbra (other) |
| Locations | 1 site (Coimbra) |
| Trial ID | NCT05296980 on ClinicalTrials.gov |
What this trial studies
This study aims to validate the REMINDER program, a multicomponent neuropsychological intervention designed for individuals at risk of dementia. Participants aged 60 and older with a high CAIDE dementia risk score will be recruited and assigned to either the REMINDER program or an active control group receiving psychoeducation. The study will evaluate immediate and long-term effects on cognitive function, neuropsychological outcomes, and conversion rates from mild cognitive impairment to Alzheimer's disease. The goal is to provide a scientifically validated intervention that can help prevent dementia in older adults.
Who should consider this trial
Good fit: Ideal candidates are community-dwelling individuals aged 60 or older with a CAIDE dementia risk score greater than 8 and no significant cognitive impairment.
Not a fit: Patients with mild cognitive impairment, dementia, or severe psychiatric disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this program could significantly reduce the risk of dementia in older adults at high risk.
How similar studies have performed: While some studies have explored cognitive training interventions, this approach of a comprehensive multicomponent program is relatively novel and has not been extensively validated.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 60 or older * CAIDE dementia risk score \>8 * Cognitive function: absence of significant cognitive impairment as per the Addenbrooke's Cognitive Examination-REVISED * Free of physical disabilities that preclude participation in the study * Willing to complete all study-related activities for 12 weeks Exclusion Criteria: * Mild cognitive impairment or dementia; * Presence of any neurological event in their medical history that could compromise actual cognition. * Presence of any severe psychiatric disorder (mild depressive and anxiety symptoms meet inclusion criteria). * Unability to travel to the site where the sessions will be delivered (if so randomization will be circumscribed between the experimental harm REMINDER online and the control group. * Illiteracy
Where this trial is running
Coimbra
- Faculty of Psychology and Educational Sciences — Coimbra, Portugal (RECRUITING)
Study contacts
- Study coordinator: Ana Rita Silva, PhD
- Email: anaritaess@fpce.uc.pt
- Phone: +351962779695
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Healthy Aging, Risk Reduction, Old Age, Dementia