Using tranexamic acid to prevent heavy bleeding after childbirth in at-risk women

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial investigates the use of tranexamic acid (TXA) to prevent postpartum hemorrhage (PPH) in women who are at higher risk during childbirth. It aims to determine the effectiveness of TXA when administered just before delivery, comparing both intramuscular and intravenous routes. Given the significant maternal mortality associated with PPH, the study seeks to provide critical evidence on the benefits and potential side effects of early TXA administration. The trial will involve women aged 18 and older with known risk factors for PPH, assessing maternal health outcomes and bleeding control.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women aged 18 years or older who are admitted to hospital to give birth vaginally or by caesarean section, who have one or more known risk factors for PPH

Exclusion Criteria:

* Women who have a clear indication or contraindication for TXA
* Women with ongoing antepartum haemorrhage

Where it's running

• Mbeya Regional Referral Hospital
  Mbeya, Tanzania Recruiting

Study contacts

• Study coordinator: Judith Lieber
• Email: imwoman@lshtm.ac.uk
• Phone: +44 (0)20 7958 8283

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.