Using the Peripheral Perfusion Index to predict extubation success
Official title: The Role of Peripheral Perfusion Index as a Predictive Factor During Weaning Process
Run by Gaziosmanpasa Research and Education Hospital · NCT07120672 · Data updated 2026-11-12
This will test whether the Peripheral Perfusion Index (PPI) can help predict if adult ICU patients will be successfully extubated after a spontaneous breathing trial.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Gaziosmanpasa Research and Education Hospital Government |
| Locations | 1 site (Istanbul) |
| Status | Recruiting |
| Started | May 8, 2025 |
| Main results expected | August 15, 2025 |
| Study ends | August 30, 2025 |
| Registry record updated | August 13, 2025 |
| Trial ID | NCT07120672 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (≥18 years) in the ICU who have been on mechanical ventilation for at least 48 hours and are scheduled for extubation after a spontaneous breathing trial are ideal candidates.
✕Probably not a fit
Patients with peripheral vascular disease, prior hand surgery, persistent hemodynamic instability, or those not planned for extubation are unlikely to benefit from this approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, single-center observational study in the Anesthesia ICU at Gaziosmanpaşa Training and Research Hospital that will enroll adult patients ventilated for at least 48 hours who undergo a spontaneous breathing trial. PPI will be measured and its ability to predict extubation failure will be compared with standard weaning criteria such as RSBI, PaO2/FiO2 ratio, and respiratory rate. Spontaneous breathing trials will be performed using pressure support (5 cmH2O) and PEEP (5 cmH2O), with extubation decisions made by the attending intensivist; patients will be monitored for reintubation for 48 hours. The study excludes patients with peripheral vascular disease, recent hand surgery, ongoing hemodynamic instability, or those who cannot be followed during the study period.
Why it matters
Potential benefit: If successful, PPI could offer a simple, noninvasive bedside measure to better predict extubation outcomes and potentially reduce reintubation and related complications.
How similar studies have gone: Small observational studies have reported correlations between PPI changes and weaning or perfusion status, but PPI is not yet validated in large multicenter trials for predicting extubation outcomes.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who have been on mechanical ventilation for at least 48 hours * Patients over 18 years of age who are planned to undergo extubation following a spontaneous breathing trial (SBT) * Patients or their legal representatives who provide informed consent to participate in the study Exclusion Criteria: * Patients for whom extubation is not planned due to hemodynamic instability * Patients with peripheral vascular disease or a history of hand surgery * Patients who die or cannot be followed up during the study period
Where it's running
-
Gaziosmanpaşa Training and Research Hospital
Istanbul, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Veysel Dinç
- Email: drvdinc@gmail.com
- Phone: +90 545 745 3472
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.