Using Tadalafil to Improve Urinary and Sexual Function After Prostate Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the efficacy of Tadalafil, a medication commonly used for erectile dysfunction, in improving lower urinary tract symptoms and erectile function in men who have undergone endoscopic enucleation of the prostate due to benign prostatic hyperplasia (BPH). The study hypothesizes that Tadalafil may alleviate storage symptoms and enhance recovery of erectile function post-surgery. It is a randomized controlled trial comparing Tadalafil to a placebo, focusing on sexually active men aged 40 and older who have not responded to previous medical treatments for BPH. The trial aims to provide insights into the relationship between urinary symptoms and erectile dysfunction following prostate surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients' age ≥ 40 years
* LUTS secondary to BOO due to BPH who failed medical treatment
* International prostate symptom scores (IPSS) \>15 and bother score (QOL) ≥ 3 (according to IPSS question 8)
* Peak urinary flow rate (Qmax) \<15 ml/sec.
* ASA (American society of anaesthesiologists) score ≤ 3.
* Sexually active men, not receiving PDE5I

Exclusion Criteria:

* Patients using nitrates, potassium channel opener, or α1-blockers doxazosin and terazosin for control of hypertension
* Patients with unstable angina pectoris, recent myocardial infarction or stroke myocardial insufficiency.
* Patients with severe hepatic or renal insufficiency.
* Patients who are sexually inactive.
* Patients with uncontrolled diabetes mellitus or neurologic condition(eg. parkinsoism)

Where it's running

• Urology and Nephrology Center
  Al Mansurah, Dakahlia Governorate, Egypt Recruiting

Study contacts

• Principal investigator: Mahmoud Laymon, MD,MRCS — urology and nephrology center mansoura university
• Study coordinator: Mahmoud Laymon, MD,MRCS
• Email: dr_mahmoudlaymon@mans.edu.eg
• Phone: 01002275698

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.