Using stellate ganglion block to help preserve arteriovenous fistulas in dialysis patients during major leg surgery
Stellate Ganglion Block for Preserving Arteriovenous Fistula in Hemodialysis Patients Undergoing Major Lower Limb Orthopedic Surgery: A Randomized Controlled Trial
This study is testing if a special nerve block can help protect the blood vessels used for dialysis in patients having major leg surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 21 Years to 75 Years |
| Sex | All |
| Sponsor | Aswan University Academic / other |
| Locations | 1 site (Aswan) |
| Trial ID | NCT06300658 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of stellate ganglion blockade (SGB) in preserving arteriovenous fistulas (AVF) in patients with chronic renal failure undergoing major lower limb orthopedic surgery. SGB is a procedure that increases blood flow and reduces vascular resistance, potentially preventing complications during surgery. The study aims to assess whether SGB can mitigate vascular reactivity and improve outcomes for hemodialysis patients during surgical procedures. Participants will be monitored for the preservation of their AVF post-surgery.
Who should consider this trial
Good fit: Ideal candidates are chronic renal failure patients aged 21 to 75 who are undergoing major lower limb orthopedic surgery.
Not a fit: Patients with psychiatric disorders, substance abuse history, or certain cardiovascular and respiratory conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could enhance the preservation of arteriovenous fistulas, improving dialysis access and outcomes for patients.
How similar studies have performed: While the use of stellate ganglion block has shown promise in other contexts, this specific application in hemodialysis patients is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 21 to 75 years. * Both sexes. * American Society of Anesthesiologists (ASA) physical status III. * Chronic renal failure (CRF) patients. * Undergoing major lower limb orthopedic surgery. Exclusion Criteria: * Psychiatric disorders. * History of substance abuse. * Ipsilateral brachial and radial artery stenosis. * Allergy to local anesthetics. * Cardiovascular and respiratory disorders. * Coagulopathy. * Use of vasoactive medications. * Obesity (body mass index \>30 kg/m2). * Smoking.
Where this trial is running
Aswan
- Aswan University — Aswan, Egypt (Recruiting)
Study contacts
- Study coordinator: Ayman M Eldemrdash, MD
- Email: ayman.mohamady@aswu.edu.eg
- Phone: 00201001296116
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.