Using resolvins to treat inflammatory low back pain
The Effect of Adding Oral Resolvins to Patients Undergoing Transforaminal Epidural Steroid Injection for Low Back Pain Treatment"
This study is testing if adding oral omega-3 supplements to steroid injections can help people with low back pain from a herniated disc feel better and recover faster.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | Bezmialem Vakif University Academic / other |
| Locations | 2 sites (Istanbul and 1 other locations) |
| Trial ID | NCT06356844 on ClinicalTrials.gov |
What this trial studies
This clinical trial evaluates the effectiveness of adding oral resolvins to transforaminal epidural steroid injections for patients suffering from lumbar disc herniation. The study involves two groups: one receiving only epidural steroids and the other receiving both oral omega-3 supplementation and epidural steroids. Resolvins, derived from omega-3 fatty acids, are believed to help reduce inflammation and promote tissue repair, potentially decreasing the need for surgical interventions. The trial aims to assess the impact of this combined treatment on pain relief and recovery.
Who should consider this trial
Good fit: Ideal candidates for this study are patients with lumbar disc herniation who are undergoing caudal epidural injections.
Not a fit: Patients with known allergies to the treatment drugs, infections, or severe comorbidities may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could provide a more effective treatment option for patients with inflammatory low back pain, potentially reducing the need for surgery.
How similar studies have performed: While the use of resolvins in this context is relatively novel, prior research has indicated their potential in reducing inflammation and pain, suggesting a promising avenue for further exploration.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * ASA I-II-III * Patients who underwent caudal epidural injection, facet joint injection and transforaminal injection due to lumbar disc herniation Exclusion Criteria: * Patients with known allergies to the drugs to be used in treatment * Infection near the puncture site * Known clotting disorders * Alcohol and drug use * Those who have used fish oil before * Disorder of consciousness * Liver failure, renal failure, advanced cardiac failure * Uncontrolled diabetes mellitus * Morbid obesity (body mass index (BMI) \> 35 kg m-2) * Female patients during pregnancy and breastfeeding * Not approving the informed consent form
Where this trial is running
Istanbul and 1 other locations
- Aylin Ceren Şanlı — Istanbul, Turkey (Türkiye) (Recruiting)
- Aylin Ceren — Istanbul, Turkey (Türkiye) (Completed)
Study contacts
- Study coordinator: zübeyde özdemir
- Email: etikkurul@bezmialem.edu.tr
- Phone: +90 2125232288
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.