Using prone positioning to predict neurological complications in ARDS patients
Changes in Cerebral Blood Flow Before and After Prone Position in Patients With ARDS Predict the Occurrence of Neurological Complications
This study looks at patients with severe breathing problems who are treated by lying on their stomachs to see if this position can help predict any brain issues they might have.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Sichuan Provincial People's Hospital Academic / other |
| Locations | 1 site (Chengdu, Sichuan) |
| Trial ID | NCT06967285 on ClinicalTrials.gov |
What this trial studies
This observational study aims to collect medical records, demographic characteristics, and clinical data from patients with moderate to severe Acute Respiratory Distress Syndrome (ARDS) who require prone positioning treatment. The study will take place at multiple hospitals in Chengdu, Sichuan, from March 2025 to March 2026. By analyzing cerebral hemodynamics, the researchers hope to identify potential neurological complications associated with this treatment approach.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older diagnosed with moderate to severe ARDS requiring prone ventilation.
Not a fit: Patients with contraindications to prone positioning or severe neurological diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the understanding of neurological risks in ARDS patients undergoing prone positioning, potentially leading to improved patient management.
How similar studies have performed: While the approach of monitoring cerebral hemodynamics in ARDS patients is not widely tested, similar studies have explored prone positioning with varying outcomes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age≥18 years * Meet the diagnostic criteria for ARDS(Acute Respiratory Distress Syndrome),with PaO₂/FiO₂\<150 mmHg,and requiring prone ventilation * Expected duration of mechanical ventilation\>48 hours * Written informed consent obtained Exclusion Criteria: * Presence of contraindications to prone positioning(e.g.,head and neck injuries,spinal instability,severe intracranial hypertension) * Severe neurological diseases(e.g.,cerebral hemorrhage,cerebral infarction,intracranial space-occupying lesions)that may affect the monitoring of cerebral hemodynamics * Life-threatening ARDS * Patients who are unable to undergo neurological assessment * Poor image quality or absence of images
Where this trial is running
Chengdu, Sichuan
- Sichuan Provincial People's Hospital, — Chengdu, Sichuan, China (Recruiting)
Study contacts
- Study coordinator: lingai Pan, PhD
- Email: panlingai2004@163.com
- Phone: 17708130236
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.