Transpulmonary Pressure-Guided Ventilation for Right Heart Protection in ARDS

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this interventional trial, researchers will apply a ventilation strategy guided by transpulmonary pressure to patients with pneumonia-induced ARDS and compare its effects on the right ventricle to the standard right-ventricle–protective approach. Eligible patients are adults with ARDS and PaO2/FiO2 ≤ 200 on invasive mechanical ventilation. The aim is to see if the transpulmonary-guided strategy lowers the incidence of acute cor pulmonale and other right-heart complications. The trial is conducted at Beijing Chao-Yang Hospital and involves careful monitoring and esophageal pressure measurement to tailor ventilator settings. Safety considerations include exclusion of patients with conditions that could confound measurements or increase risk, such as high intracranial pressure or active air leakage in the lungs.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥ 18 years old
2. ARDS caused by pneumonia (New Global Definition of ARDS)
3. PaO2/FiO2≤200mmHg
4. Received invasive mechanical ventilation
5. Sign the informed consent form

Exclusion Criteria:

1. Invasive mechanical ventilation duration \> 48 hours
2. History of pulmonary hypertension caused by various reasons
3. Severe arrhythmia
4. BMI\>30kg/m2
5. Contraindications to inserting an esophageal catheter (including recent esophageal injury or surgery, severe coagulopathy (platelets \< 5×10⁹/L or INR \> 4)
6. Pregnant and lactating women
7. Lung transplant recipient
8. High-risk factors for increased intracranial pressure (including intracranial hemorrhage, cerebral contusion, cerebral edema, intracranial space-occupying lesions, etc.)
9. Active air leakage in the lungs (pneumothorax, mediastinal emphysema, bronchopleural fistula, air leakage from closed thoracic drainage tubes, etc.)
10. Neuromuscular disease
11. Already received salvage measures (iNO, ECMO, prone position, high-frequency oscillatory ventilation)
12. Severe liver failure
13. Participated in other ARDS-related studies within 30 days

Where it's running

• Beijing Chao-Yang Hospital
  Beijing, China Recruiting

Study contacts

• Study coordinator: Xiao Tang, MD
• Email: tangxiao0928@163.com
• Phone: 86013811089795

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.