PRE-VAIL: reducing enteral feeding before prone positioning for severe ARDS

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study enrolls adults with moderate-to-severe ARDS who are mechanically ventilated and expected to require ICU care. Patients planned for prone positioning receive either a reduced dose of enteral nutrition before being turned prone (experimental) or no reduction in enteral nutrition (control). Investigators monitor intragastric pressure, signs of gastric retention and feeding tolerance, along with safety outcomes during and after prone sessions. The trial is conducted at a single center in the ICU setting.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years old
* Within 24 hours of admission to the ICU, one or more organ systems have failed (the Sequential Organ Failure Assessment (SOFA) score of any single organ system is ≥2)
* Meet the diagnostic criteria for moderate/severe ARDS (even after optimizing the ventilation Settings, the oxygenation index is still \< 150mmHg and PEEP is still ≥5 cm H2O)
* It is expected to stay in the ICU for more than 48 hours

Exclusion Criteria:

* There are contraindications for the prone position
* There are contraindications for EN, preventing the initiation of early EN (≤48 hours)
* Expected to die within 48 hours
* Pregnancy

Where it's running

• The First Hospital of Jilin University
  Changchun, Jilin, China Recruiting

Study contacts

• Study coordinator: Youquan Wang, M.D.
• Email: wangyq20@mails.jlu.edu.cn
• Phone: +8615584299391

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.