Using preconditioned stem cells to improve fat grafting for facial deformities
Supplementation of Autologous Fat Grafts with Curcumin Preconditioned Adipose-Derived Stem Cells in the Treatment of Facial Contour Deformities
This study is testing if using special stem cells treated with curcumin can make fat grafting for facial deformities work better than standard methods.
Quick facts
| Phase | Phase 1 |
|---|---|
| Study type | Interventional |
| Enrollment | 24 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | All |
| Sponsor | University of the Punjab Academic / other |
| Locations | 1 site (Lahore, Punjab Province) |
| Trial ID | NCT05610878 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of curcumin preconditioned adipose-derived stem cells (ASCs) in enhancing fat grafting procedures compared to naïve ASCs and conventional fat grafting techniques. Patients with facial contour deformities due to conditions like Romberg Disease, Craniofacial Microsomia, and burn scars will undergo fat grafting using these different methods. The process involves collecting adipose tissue, isolating ASCs, and preparing them for grafting under sterile conditions. The aim is to determine which method provides the best aesthetic outcomes for patients.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-50 with a body mass index of 20-30 who are suitable for liposuction.
Not a fit: Patients with systemic disorders, local infections, or significant risk factors such as uncontrolled diabetes or smoking may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve the aesthetic results of fat grafting for patients with facial deformities.
How similar studies have performed: While the use of stem cells in fat grafting has been explored, the specific approach of using curcumin preconditioning is relatively novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria * Age 18-50 years (male or female) * Body-mass index 20-30 kg/m² * Suitable for liposuction as assessed by the expected cosmetic results * Provided signed informed consent Exclusion criteria * Systemic disorders include autoimmune diseases, hemorrhagic diseases, bone marrow aplasia, sepsis, cancer, and others * Local disorders include acne, infections and others * Risk factors include smoking, uncompensated diabetes, hypertension, and allergy to the drugs used for general anesthesia * Microbiological contamination of either the cell culture or the transplanted tissue
Where this trial is running
Lahore, Punjab Province
- Stem Cell Laboratory, Jinnah Burn and Reconstructive Surgery Center (JB&RSC) — Lahore, Punjab Province, Pakistan (Recruiting)
Study contacts
- Principal investigator: Azra Mehmood, PhD — Center of Excellence in Molecular Biology (CEMB), University of the Punjab, Lahore
- Study coordinator: Azra Mehmood, PhD
- Email: azra_mehmood@hotmail.com
- Phone: +92-333-4107008
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.