Using preconditioned stem cells to improve fat grafting for facial deformities

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of curcumin preconditioned adipose-derived stem cells (ASCs) in enhancing fat grafting procedures compared to naïve ASCs and conventional fat grafting techniques. Patients with facial contour deformities due to conditions like Romberg Disease, Craniofacial Microsomia, and burn scars will undergo fat grafting using these different methods. The process involves collecting adipose tissue, isolating ASCs, and preparing them for grafting under sterile conditions. The aim is to determine which method provides the best aesthetic outcomes for patients.

Why it matters

Who can join: the full rules

Inclusion criteria

* Age 18-50 years (male or female)
* Body-mass index 20-30 kg/m²
* Suitable for liposuction as assessed by the expected cosmetic results
* Provided signed informed consent

Exclusion criteria

* Systemic disorders include autoimmune diseases, hemorrhagic diseases, bone marrow aplasia, sepsis, cancer, and others
* Local disorders include acne, infections and others
* Risk factors include smoking, uncompensated diabetes, hypertension, and allergy to the drugs used for general anesthesia
* Microbiological contamination of either the cell culture or the transplanted tissue

Where it's running

• Stem Cell Laboratory, Jinnah Burn and Reconstructive Surgery Center (JB&RSC)
  Lahore, Punjab Province, Pakistan Recruiting

Study contacts

• Principal investigator: Azra Mehmood, PhD — Center of Excellence in Molecular Biology (CEMB), University of the Punjab, Lahore
• Study coordinator: Azra Mehmood, PhD
• Email: azra_mehmood@hotmail.com
• Phone: +92-333-4107008

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.