Using OCT Angiography to Diagnose and Evaluate Wet AMD
Official title: Optical Coherence Tomography Angiography in Neovascular Age-related Macular Degeneration
Run by Oregon Health and Science University · NCT02253030 · Data updated 2026-11-12
This study is testing if a special imaging technique can help doctors find new blood vessels in older adults with wet age-related macular degeneration and see how blood flow might affect the condition.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 50 Years to 100 Years |
| Sex | All |
| Enrollment | 160 (estimated) |
| Sponsor | Oregon Health and Science University Academic / other |
| Locations | 1 site (Portland, Oregon) |
| Status | Recruiting |
| Started | September 2014 |
| Main results expected | December 2026 |
| Study ends | December 2026 |
| Registry record updated | February 12, 2024 |
| Trial ID | NCT02253030 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 50 and older with treatment-naïve neovascular AMD showing active new blood vessel growth.
✕Probably not a fit
Patients with significant kidney disease, severe hypertension, or those who have previously undergone macular laser treatment may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to utilize optical coherence tomography (OCT) angiography to diagnose the presence of new blood vessels in patients with wet age-related macular degeneration (AMD). It will also evaluate patients undergoing treatment for this condition and investigate whether reduced blood flow to the choroid is a risk factor for developing wet AMD. The study will include adults aged 50 and older with treatment-naïve neovascular AMD and healthy individuals for comparison. The methodology focuses on advanced imaging techniques to enhance understanding and management of wet AMD.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic and treatment strategies for patients with wet AMD.
How similar studies have gone: Other studies utilizing OCT angiography have shown promise in diagnosing and managing retinal conditions, indicating a potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria (Groups with wet AMD): * Adults aged 50 and older with clinical findings of treatment-naïve (never treated) neovascular AMD with active new blood vessel growth confirmed by clinical testing will be considered Inclusion Criteria (Group with healthy eyes) * No evidence of retinal disease * Refractive error greater than +3.00 diopters or -7.00 diopters (glasses Rx) * No recent eye surgery in the last 4 months * No significant cataract to interfere with the quality of the imaging Exclusion Criteria (All Groups): * Inability to give informed consent * Significant kidney disease * Blood pressure greater than 180/110 * Previous macular laser treatment * Inability to maintain stable fixation during OCT imaging * Visual acuity worse than 20/200
Where it's running
-
Casey Eye Institute, Oregon Health & Science University
Portland, Oregon, United States Recruiting
Study contacts
- Principal investigator: Steven Bailey, MD — Oregon Health and Science University
- Study coordinator: George Pacheco, COA
- Email: pachecge@ohsu.edu
- Phone: 503-494-7398
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.