Using non-invasive ventilation during fiber-optic bronchoscopy

Efficacy and Safety of Using Non-invasive Ventilation Assisted Fiber-optic Bronchoscopy

This study is testing if using a special breathing machine during a lung procedure helps patients breathe better compared to regular oxygen therapy.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 100 (estimated)
• Ages: 18 Years to 70 Years
• Sex: All
• Sponsor: Mansoura University (Academic / other)
• Locations: 1 site (Al Mansurah)
• Trial ID: NCT06115395 on ClinicalTrials.gov

What this trial studies

This study evaluates the effects of bi-level positive airway pressure ventilation on patients undergoing fiber-optic bronchoscopy for diagnostic or therapeutic purposes. Patients will be divided into four groups based on their oxygen levels and the type of ventilation they receive before, during, and after the procedure. Comprehensive assessments including medical history, physical examination, and imaging studies will be conducted to determine eligibility and monitor outcomes. The goal is to compare the benefits and drawbacks of non-invasive ventilation versus conventional oxygen therapy in these patients.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older who require bronchoscopy for diagnostic or therapeutic reasons.

Not a fit: Patients with severe respiratory or cardiac conditions, or those unable to cooperate with the procedure, may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could improve patient outcomes and comfort during bronchoscopy procedures.

How similar studies have performed: While the use of non-invasive ventilation in bronchoscopy is being explored, this specific approach is relatively novel and has not been extensively tested in prior studies.

Eligibility criteria

Inclusion Criteria:

* Patients who admitted to the pulmonology ward or intensive care unit with any (diagnostic and/or therapeutic) bronchoscopy indication.

  1. Age 18 years or more.
  2. Patients accepted to participate in the study.

Exclusion Criteria:

* Patients with:

  1. Cardiac or respiratory arrest.
  2. Impaired consciousness or confusion.
  3. Type II respiratory failure.
  4. Hemodynamic instability.
  5. Inability to cooperate or to protect the airway.
  6. Vomiting, bowel obstruction, recent upper gastrointestinal tract surgery and esophageal injury.
  7. Patients refusing participation in the study.
  8. Patients unfit for NIV and or NIV mask.
  9. Intubation and or invasive ventilation candidates.
  10. Presence of contraindications for bronchoscopy procedure such as insufficient platelet number or coagulopathy.

Where this trial is running

Al Mansurah

• Walaa Maher Abd ElAziz, — Al Mansurah, Egypt (Recruiting)

Study contacts

• Study coordinator: Walaa Abd El Aziz, MD

Conditions Lung; Diseases; non- invasive ventilation; fiber-optic bronchoscopy.