Using MRI to predict disability progression in multiple sclerosis patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to identify MRI biomarkers that can predict the transition from relapsing-remitting multiple sclerosis (RRMS) to secondary progressive multiple sclerosis (SPMS). By utilizing ultra-high field 7T magnetic resonance spectroscopy, the study seeks to enhance the visualization of chronic inflammatory lesions and measure brain atrophy with greater precision. The research focuses on analyzing cerebral metabolites to gain insights into cellular energy metabolism and neurodegeneration. This approach could potentially reduce the diagnostic uncertainty associated with SPMS.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years,
* Duration of disease ≤ 25 years,
* Irreversible disability ≤ 7 (permanent wheelchair use) on the EDSS scale

Exclusion Criteria:

* Other progressive neurological disease,
* Isolated radiologic syndrome (RIS),
* Severe psychiatric pathology not in balance,
* Change in dosage, discontinuation or initiation of a psychotropic treatment within the last month,
* Change in background MS treatment for less than 3 months,
* A course of corticosteroids (oral or intravenous) for less than one month,
* Patient with a contraindication to MRI: pregnancy, metallic ocular foreign body (accidental splinters or others), pacemaker, implantable defibrillator, neurostimulator not compatible with MRI 7.0 T, cochlear implants and in general any electronic medical equipment implanted in an irremovable way: metallic cardiac valve, vascular clips (formerly implanted on cranial aneurysm), metallic prosthesis...),
* Illiterate and non-French speaking patient: patient who is partially or completely unable to read and write French.
* Patient benefiting from reinforced protection, i.e. minor, subject deprived of liberty by a judicial or administrative decision, subject staying in a health or social establishment, adult under legal protection and finally patient in emergency situation,
* Pregnant or breastfeeding women, women of childbearing age who do not have effective contraception (hormonal/mechanical: per os, injectable, transcutaneous, implantable, intrauterine device, or surgical: tubal ligation, hysterectomy, total oophorectomy)

Where it's running

• PoitiersUH
  Poitiers, France Recruiting

Study contacts

• Study coordinator: Amelie Dos Santos, Dr
• Email: amelie.dos-santos@chu-poitiers.fr
• Phone: +33.5.49.44.44.46

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.