Using micro-osteoperforations to speed up clear aligner treatment for crowded teeth
Official title: Evaluating the Efficacy of Micro-Osteoperforations Technique on the Orthodontic Tooth Movement Acceleration of Dental Crowding Cases Treated With Clear Aligners: A Randomized Controlled Clinical Trial
Run by Hama University · NCT05492773 · Data updated 2026-11-12
This study is testing if a new technique called micro-osteoperforations can help adults with crowded teeth get better results and feel more comfortable while using clear aligners.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 26 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Hama University Academic / other |
| Locations | 1 site (Hama) |
| Status | Recruiting |
| Started | December 10, 2026 |
| Main results expected | May 4, 2027 |
| Study ends | December 4, 2027 |
| Registry record updated | September 16, 2026 |
| Trial ID | NCT05492773 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults with moderate anterior mandibular crowding who have completed their permanent dentition and are seeking orthodontic treatment with clear aligners.
✕Probably not a fit
Patients with systemic diseases affecting bone movement, those on medications that interfere with pain perception, or individuals with poor oral hygiene may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of the micro-osteoperforations technique in accelerating orthodontic tooth movement in patients with moderate mandibular anterior crowding undergoing treatment with clear aligners. Participants will be divided into two groups: one receiving traditional clear aligners with micro-osteoperforations and the other receiving clear aligners alone. The study will assess not only the speed of tooth movement but also patient pain levels and satisfaction throughout the treatment process. This approach aims to improve compliance and outcomes for adult patients who prefer less invasive orthodontic options.
Why it matters
Potential benefit: If successful, this technique could significantly reduce treatment time for patients using clear aligners, leading to faster results and improved patient satisfaction.
How similar studies have gone: While the micro-osteoperforations technique is a relatively novel approach in orthodontics, similar methods have shown promise in accelerating tooth movement in other contexts.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Completion of permanent dentition (except third molars) * Moderate crowding (4-6 mm according to Little's index) * Absence of medications intake that interferes with pain perception for at least one week before the beginning of the treatment * Number of aligners ≥ 8 aligners. Exclusion Criteria: * • Systematic diseases that could affect bone and tooth movement and no contraindication avoid oral surgery * Medical conditions that affect tooth movement (Corticosteroid, NSAIDs) * Patients had previous orthodontic treatments * Poor oral hygiene or concurrent periodontal disease
Where it's running
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Hama University
Hama, Syria Recruiting
Study contacts
- Principal investigator: Zouha Barram — Hama University
- Study coordinator: Zouha Barram, MSc Student
- Email: barramzouha@gmail.com
- Phone: 00963964617577
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.