Using methadone to improve recovery after cardiac surgery
Official title: Methadone and Quality of Postoperative Recovery
Run by Endeavor Health · NCT03168958 · Data updated 2026-11-12
This study is testing if giving methadone during heart surgery can help patients feel less pain and recover better compared to those who get a placebo.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 90 Years |
| Sex | All |
| Enrollment | 130 (estimated) |
| Sponsor | Endeavor Health Academic / other |
| Locations | 1 site (Evanston, Illinois) |
| Status | Recruiting |
| Started | December 25, 2018 |
| Main results expected | May 25, 2021 |
| Study ends | July 25, 2021 |
| Registry record updated | August 24, 2020 |
| Trial ID | NCT03168958 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults scheduled for elective cardiac surgery requiring cardiopulmonary bypass.
✕Probably not a fit
Patients with significant renal or hepatic dysfunction, severe pulmonary disease, or a history of opioid abuse may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the effectiveness of methadone as a long-acting opioid for managing postoperative pain in patients undergoing cardiac surgery. By administering methadone during the induction of anesthesia, the study aims to reduce pain intensity and the need for additional analgesics in the early recovery period. The trial will compare recovery quality scores between patients receiving methadone and those receiving saline as a control. The goal is to determine if methadone can enhance overall postoperative recovery and patient satisfaction.
Why it matters
Potential benefit: If successful, this approach could lead to improved pain management and recovery experiences for cardiac surgery patients.
How similar studies have gone: Previous studies have shown promising results with methadone in postoperative pain management, suggesting this approach may be effective.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients presenting for elective cardiac surgery with CPB will be eligible for enrollment Exclusion Criteria: * Preoperative renal failure requiring dialysis or severe renal dysfunction (serum creatinine \> 2.0 mg/dL) * Significant hepatic dysfunction (liver function tests \> 2 times upper normal limit) * Pulmonary disease necessitating home oxygen therapy * Preoperative requirement for inotropic agents or intraaortic balloon pump to maintain hemodynamic stability * Allergy to methadone or fentanyl * Significant preoperative pain requiring treatment with opioids or recent history of opioid abuse * Inability to speak or read the English language or neurologic conditions that may impair the ability to complete the QoR 40 questionnaire.
Where it's running
-
NorthShore University HealthSystem
Evanston, Illinois, United States Recruiting
Study contacts
- Principal investigator: Glenn S Murphy, MD — Endeavor Health
- Study coordinator: Glenn S Murphy, MD
- Email: dgmurphy2@yahoo.com
- Phone: 847-570-2760
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.