Using memantine to protect memory and cognition during craniospinal irradiation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the effectiveness of memantine in preserving memory and neurocognitive function in patients undergoing craniospinal irradiation (CSI) for conditions like medulloblastoma. Participants will be randomly assigned to receive either memantine alongside standard treatment or standard treatment alone. The study aims to assess neurocognitive outcomes through tests conducted before and after radiation therapy. By investigating memantine's potential benefits, the trial seeks to address the cognitive decline often experienced by survivors of CNS tumors post-treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age at irradiation: 5 to 39 years
* Planned for CSI (with or without boost dose) with or without systemic chemotherapy
* Informed consent or assent taken
* Karnofsky Performance Status / Lansky Performance Status ≥ 60

Exclusion Criteria:

* Re-irradiation
* Prior exposure to memantine
* Inability to undergo Wechsler test

Where it's running

• Tata Memorial Hospital
  Mumbai, Maharashtra, India Recruiting

Study contacts

• Study coordinator: Tejpal Gupta, MD
• Email: drtejpalgupta@gmail.com
• Phone: 02224177000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.