Hyperbaric oxygen for long COVID cognitive and fatigue symptoms

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with persistent cognitive decline and other post-COVID symptoms for at least three months will be enrolled and receive either hyperbaric oxygen therapy (HBOT) or a sham procedure. Participants undergo multiple in-person HBOT or sham sessions and are followed with cognitive tests, symptom questionnaires, and brain MRI when possible. Key exclusion criteria include prior HBOT, traumatic brain injury or other non-COVID brain pathology, active malignancy, active smoking, and chest or ear conditions incompatible with pressure changes. The trial is conducted at Assaf-Harofeh Medical Center and requires attending scheduled clinic visits for treatment and assessments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age above 18 years
2. Reported post COVID-19 cognitive deterioration that effect quality of life and persist at least 3 months after confirmed infection.
3. Subject willing and able to read, understand and sign an informed consent

Exclusion Criteria:

1. Inability to attend scheduled clinic visits and/or comply with the study protocol
2. History of traumatic brain injury (TBI) or any other non COVID brain pathology
3. Active malignancy
4. Substance use at baseline
5. Severe or unstable physical disorders or major cognitive deficits at baseline
6. HBOT for any reason prior to study enrolment
7. Chest pathology incompatible with pressure changes (including moderate to severe asthma)
8. Ear or Sinus pathology incompatible with pressure changes
9. An inability to perform an awake brain MRI
10. Active smoking

Where it's running

• Assaf-Harofeh medical center
  Tsrifin, Israel Recruiting

Study contacts

• Principal investigator: Shai a Efrati, MD — Asaf-Harofhe MC
• Study coordinator: Shani Zilberman-Itskovich, Dr.
• Email: shani.zilberman@mail.huji.ac.il
• Phone: 97289979383

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.