Using Lipo-Curcumin Gel with Scaling and Root Planing for Treating Stage III Periodontitis
Clinical Evaluation of Lipo-Curcumin Gel in Association with SRP for the Treatment of Stage III Periodontitis: a Randomized and Controlled Clinical Trial.
This study is testing whether using a special lipo-curcumin gel along with a common dental cleaning method can help people with stage III periodontitis more than other treatments.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | G. d'Annunzio University Academic / other |
| Locations | 1 site (Chieti, CH) |
| Trial ID | NCT06624241 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to evaluate the effectiveness of Scaling and Root Planing (SRP) combined with lipo-curcumin gel compared to other treatments including SRP with lipo gel, discharged gel, and SRP alone. A total of 40 patients diagnosed with stage III periodontitis will be randomly assigned to one of four treatment groups. The study will last for 12 months and will assess clinical and radiographic outcomes to determine the best treatment approach. Each treatment will involve ultrasonic scaling and hand instrumentation under local anesthesia, followed by the application of the respective gel.
Who should consider this trial
Good fit: Ideal candidates are non-smokers or former smokers who have not received periodontal treatment in the last three months and have a diagnosis of stage III periodontitis.
Not a fit: Patients with uncontrolled systemic diseases or those who have recently received antibiotic therapy or chronic NSAID/steroid treatment may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could improve periodontal health and reduce attachment loss in patients with stage III periodontitis.
How similar studies have performed: While the use of curcumin in periodontal treatment is promising, this specific combination of lipo-curcumin gel with SRP has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with a diagnosis of periodontitis stage III (grades A to C) * on-smokers or former smokers who quit at least 1 year ago, and had not received any periodontal treatment in the 3 months prior to recruitment * FMPS \< 20% at baseline * Furcation not involved * Not Pregnant or Lactating * Signed informed consent Exclusion Criteria: * Presence of uncontrolled systemic diseases that could affect treatment outcomes such as diabetes mellitus with an HbA1C\>7%, rheumatoid arthritis or any form of immunosuppression * Patients that had received systemic or local delivery of antibiotic therapy 6 weeks before enrollment * Chronic intake of NSAIDs or steroids, currently
Where this trial is running
Chieti, CH
- G. d'Annunzio University — Chieti, Ch, Italy (Recruiting)
Study contacts
- Study coordinator: Michele Paolantonio, DDS, MD
- Email: michelepaolantonio@gmail.com
- Phone: 3395204073
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.