Using limb occlusion therapy to improve recovery in patients with aneurysmal subarachnoid hemorrhage

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of remote ischemic conditioning (RIC) on patients who have experienced an aneurysmal subarachnoid hemorrhage (aSAH). Participants will be divided into two groups: one receiving RIC through limb occlusion therapy and the other receiving a sham treatment. The primary aim is to assess whether RIC can enhance long-term functional independence compared to the sham group. The study addresses the critical need for effective interventions to prevent delayed cerebral ischemia, a common and serious complication following aSAH.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aneurysmal subarachnoid hemorrhage confirmed by computed tomography (CT) with aneurysm origin confirmed by computed tomography angiography (CTA) or digital subtraction angiography (DSA)
* Aneurysmal subarachnoid hemorrhage symptom-onset ≤ 3 days
* Aneurysm protected by clipping or coiling
* Independent in daily living before symptom onset (mRS ≤ 2)

Exclusion Criteria:

* Subarachnoid hemorrhage caused by a lesion other than cerebral aneurysm
* Symptomatic vasospasm at the time of enrollment
* Previous cerebral lesion e.g. symptomatic cerebral infarction (\>2cm), multiple sclerosis, symptomatic intracerebral hemorrhage, tumour, prior neurosurgery (excluding prior clipping or coiling of cold aneurysms without complications).
* History of severe peripheral vascular disease or signs of severe peripheral vascular disease on physical examination
* History of deep vein thrombosis or signs of deep vein thrombosis on physical examination
* Kidney involvement or prior kidney disease with an estimated glomerular filtration rate (eGFR) below safe levels for contrast infusion in relation to CT-perfusion.
* Pregnancy (Women of child-bearing age will have serum-Humane Choriogonadotropine taken prior to final inclusion. If pregnancy cannot be ruled out,the patient can't be included. Women with a safe birth control method will be encouraged to use this method during the entire period of active treatment.)
* Concomitant other acute life-threatening medical or surgical condition

Where it's running

• Department of Neurosurgery, Aarhus University Hospital
  Aarhus N, Danmark, Denmark Recruiting

Study contacts

• Principal investigator: Grethe Andersen, Prof., MD — Department of Neurology, Aarhus University Hospital
• Study coordinator: Kim M Ørskov, MD
• Email: kimoer@rm.dk
• Phone: +4542791933

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.