Using Lignocaine for Pain Relief in Gynecological Surgery
Analgesic Effect of IntraPeritoneal LIGNOcaine in Gynaecological Open Surgery: A Double-blinded Randomised Placebo-controlled Trial (IP LIGNO Trial)
This study tests if using lignocaine directly in the abdomen can help women feel less pain after gynecological surgery compared to using regular saline.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 112 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | University of Malaya Academic / other |
| Locations | 1 site (Kuala Lumpur) |
| Trial ID | NCT05897385 on ClinicalTrials.gov |
What this trial studies
This study investigates the effectiveness of intraperitoneal lignocaine as a method for managing postoperative pain in women undergoing gynecological open surgery. By administering lignocaine directly into the abdominal cavity, the study aims to block pain signals from visceral organs while minimizing systemic absorption and associated side effects. The trial compares the analgesic effects of lignocaine against normal saline to determine its efficacy in reducing postoperative complications and improving recovery times.
Who should consider this trial
Good fit: Ideal candidates for this study are adult women aged 18 to 60 who are scheduled for gynecological open surgery with a midline or transverse incision.
Not a fit: Patients undergoing laparoscopic surgery or those with allergies to lignocaine or significant comorbidities may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve pain management for patients undergoing gynecological surgeries, leading to faster recovery and fewer complications.
How similar studies have performed: Previous randomized controlled trials have shown positive outcomes for intraperitoneal lignocaine in reducing postoperative visceral pain after laparoscopic surgery, suggesting potential success for this approach in open surgery as well.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * all adult women (American Society of Anesthesiologists (ASA) who \>18 years old and \<60 years old * gynaecological open surgery with midline or transverse laparotomy incision (below or above umbilicus) Exclusion Criteria: * laparoscopic surgery * allergic to lignocaine * history of cardiac, vascular or liver disease * ASA 3-5 or * body mass index \<18/ or \>40
Where this trial is running
Kuala Lumpur
- University of Malaya — Kuala Lumpur, Malaysia (Recruiting)
Study contacts
- Principal investigator: Pui San Loh, MBBS — University of Malaya
- Study coordinator: Ka Ting Ng, MBChB
- Email: katingng1@gmail.com
- Phone: +60379492411
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.