Using Ketorolac to Manage Pain After Egg Retrieval
Official title: A Randomized Blinded Placebo Controlled Trial Assessing Ketorolac (Toradol) at Oocyte Retrieval
Run by Shady Grove Fertility Reproductive Science Center · NCT06026553 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing if Ketorolac can help women manage pain after egg retrieval during IVF and reduce their need for stronger pain medications.
Quick facts
| Phase | Phase 1 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 45 Years |
| Sex | Women only |
| Enrollment | 400 (estimated) |
| Sponsor | Shady Grove Fertility Reproductive Science Center Academic / other |
| Locations | 2 sites (Rockville, Maryland and 1 other locations) |
| Trial ID | NCT06026553 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are women over 18 years old who are scheduled to undergo oocyte retrieval as part of an IVF cycle.
✕Probably not a fit
Patients with known allergies to Ketorolac or those with certain medical conditions that contraindicate its use will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to evaluate the effectiveness of Ketorolac (Toradol), a nonsteroidal anti-inflammatory drug, in managing postoperative pain and reducing the need for narcotics following oocyte retrieval in women undergoing in vitro fertilization (IVF). Approximately 400 women will be randomly assigned to receive either Ketorolac or a placebo after their egg retrieval procedure. The study will assess pain control and narcotic usage, with the goal of minimizing opioid exposure and its associated risks. The trial is designed as a prospective, randomized, blinded, placebo-controlled study to ensure robust results.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management strategies for women undergoing egg retrieval, reducing reliance on narcotics.
How similar studies have gone: Previous studies have shown that Ketorolac is effective for postoperative pain control, suggesting that this approach may yield positive results.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Signed informed consent 2. Females over 18 years of age who are scheduled to undergo oocyte retrieval 3. Patients must be able to read and understand written English or have an appropriate certified medical translator available. 4. Standard eligibility criteria to undergo IVF and embryo transfer at Shady Grove Exclusion Criteria: 1. Known allergy to ketorolac 2. Those with known medical conditions precluding them from ketorolac use (active peptic ulcer disease, recent or history of hemorrhage or perforation, known renal or hepatic insufficiency, suspected or confirmed cerebrovascular bleeding, hemorrhagic diathesis, bleeding disorders, recent myocardial infarction, or stroke.) 3. BMI ≥ 40 kg/m2 4. History of substance abuse 5. Chronic opioid use 6. Transabdominal oocyte retrieval
Where it's running
-
Shady Grove Fertility Reproductive Science Center
Rockville, Maryland, United States Recruiting -
Shady Grove Fertility Reproductive Science Center
Fairfax, Virginia, United States Recruiting
Study contacts
- Principal investigator: Kathleen Devine, MD — Shady Grove Fertility Reproductive Science Center
- Study coordinator: Tasha Newsome
- Email: tasha.newsome@sgfertility.com
- Phone: (301)545-1289
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.