Using intravenous fluids to prevent pancreatitis after ERCP procedures

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of various short-term intravenous fluid regimens in preventing post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis, a common and serious complication. The trial aims to provide data on the efficacy of these fluid treatments, which could significantly influence ERCP practices globally. By focusing on patients undergoing ERCP, the study seeks to address a critical gap in current medical knowledge regarding preventive measures for this condition.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. age 18-75 years (due to higher likelihood of undiagnosed cardiac disease or renal insufficiency in patients \>75 years of age)
2. ability to give informed consent
3. native major papillary anatomy
4. ability and willingness to obtain bloodwork the day after ERCP

Exclusion Criteria:

1. prior ERCP with sphincterotomy and/or sphincteroplasty
2. confirmed or suspected cholangitis or sepsis
3. confirmed pancreatitis, hyperlipasemia, or hyperamylasemia within the preceding 7 days
4. NYHA Class II or greater heart failure
5. active pulmonary edema
6. myocardial infarction or ischemia within the preceding 3 months
7. renal insufficiency with CrCl \< 40 mL/minute
8. CPT Class B or C cirrhosis and/or end-stage liver disease
9. room air oxygen saturation \<90% or requirement of home O2
10. hypernatremia with Na+ ≥ 150 mEq/L or Na+ \<130 mEq/L
11. uncontrolled hypertension or hypotension
12. pregnant status

Where it's running

• Peter Lougheed Centre
  Calgary, Alberta, Canada Recruiting

Study contacts

• Study coordinator: Nauzer Forbes, MD, MSc
• Email: nauzer.forbes@ucalgary.ca
• Phone: 403-880-8508

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Can a rectal NSAID alone prevent pancreatitis after ERCP instead of also placing a pancreatic duct stent?

  This trial will see if giving a rectal NSAID by itself prevents pancreatitis after ERCP in high-risk adults as well as giving both a rectal NSAID and a pancreatic duct stent.

  Recruiting at 11 sites Air Force Military Medical University, China · Beijing, Beijing Municipality and 14 other locations · NCT07117318

• Understanding genetic and pharmacokinetic factors in post-ERCP pancreatitis

  This study is trying to find out how genetic factors and how the body processes medications affect the risk of developing pancreatitis after a specific procedure called ERCP.

  Recruiting Radboud University Medical Center · Nijmegen, Gelderland · NCT05267379

• Using Tacrolimus and Indomethacin to Prevent Pancreatitis After ERCP

  This study is testing if taking a medication called tacrolimus before a procedure to remove bile duct stones can help prevent pancreatitis in patients.

  Recruiting at 2 sites Phase 3 Johns Hopkins University · Baltimore, Maryland and 4 other locations · NCT05252754

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.