Using Intestinal Ultrasound to Improve Treatment for Inflammatory Bowel Disease
Role of Intestinal Ultrasound in Treat to Target Strategy in the Management of Inflammatory Bowel Disease : the IUS-TTT Study
This study is testing if using a simple ultrasound of the intestines can help doctors better manage treatment for people with inflammatory bowel disease, like Crohn's disease and ulcerative colitis.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Asian Institute of Gastroenterology, India Academic / other |
| Locations | 1 site (Hyderabad, Telangana) |
| Trial ID | NCT06534216 on ClinicalTrials.gov |
What this trial studies
This observational pilot study evaluates the effectiveness of bedside Intestinal Ultrasound (IUS) as a non-invasive tool in the Treat-to-Target strategy for managing Inflammatory Bowel Disease (IBD), specifically Crohn's disease and ulcerative colitis. The study will monitor patients over a 6-12 month period to assess transmural response and remission, while also predicting clinical and biochemical responses at 3 months and mucosal healing at 6-12 months. Participants will undergo IUS at multiple time points, alongside other clinical assessments, to determine the feasibility and impact of IUS in routine care for IBD management.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years with active Crohn's disease or ulcerative colitis meeting specific endoscopic criteria.
Not a fit: Patients with Crohn's disease restricted to non-terminal ileum, isolated proctitis in ulcerative colitis, or those with a BMI over 30 may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved disease management and therapeutic outcomes for patients with inflammatory bowel disease.
How similar studies have performed: While the use of Intestinal Ultrasound is growing, this specific application within a Treat-to-Target strategy is relatively novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults over the age of 18 years. * Active Crohn's disease, defined as a Simple Endoscopic Score for Crohn's Disease of 3 or higher. * Active ulcerative colitis, defined as an Ulcerative Colitis Endoscopic Index of Severity of 2 or higher. Exclusion Criteria: * Age \< 18 years * Intestinal ultrasound for assessment of response to therapy * Intestinal ultrasound for clinically asymptomatic disease * Pregnancy and lactating mothers
Where this trial is running
Hyderabad, Telangana
- Asian Institute of Gastroenterology — Hyderabad, Telangana, India (Recruiting)
Study contacts
- Study coordinator: Partha Pal, MD, DNB
- Email: partha0123456789@gmail.com
- Phone: 91-8945906823
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.