Using hyaluronan-enriched medium to improve pregnancy rates
Effect of Hyaluronan-enriched Medium on the Cumulative Ongoing Pregnancy Rate: a Prospective Randomized Trial
This study is testing if using a special medium with hyaluronan during egg retrieval can help improve pregnancy rates for patients trying to conceive.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 400 (estimated) |
| Ages | 18 Years to 40 Years |
| Sex | Female |
| Sponsor | KU Leuven Academic / other |
| Locations | 1 site (Leuven) |
| Trial ID | NCT04697823 on ClinicalTrials.gov |
What this trial studies
This study evaluates the impact of hyaluronan-enriched transfer medium on the cumulative ongoing pregnancy rate in patients undergoing oocyte retrieval. It involves a randomized controlled approach where patients with their own oocytes or embryos and specific eligibility criteria will be treated with this enriched medium. The goal is to determine if this intervention can enhance pregnancy outcomes compared to standard practices.
Who should consider this trial
Good fit: Ideal candidates are women under 40 years old who are undergoing a second or third oocyte retrieval without a clinical ongoing pregnancy from previous attempts.
Not a fit: Patients who are older than 40 years or have a BMI over 32 may not benefit from this study.
Why it matters
Potential benefit: If successful, this could lead to higher pregnancy rates for patients undergoing fertility treatments.
How similar studies have performed: Other studies have shown promising results with similar approaches using enriched media in fertility treatments.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with own oocytes/embryos; * Patients with female age at 1st OR in the study \<40 year; * Patients planned for a 2nd oocyte retrieval, with no clinical ongoing pregnancy after the previous oocyte retrieval * Patients planned for a 3rd oocyte retrieval with no clinical ongoing pregnancy after previous oocyte retrievals * Patients with female age at 1st OR in the study \<40 year; * Patients with BMI ≤32; * Patients with written informed consent; Exclusion Criteria: \-
Where this trial is running
Leuven
- Leuven University Fertility Center — Leuven, Belgium (Recruiting)
Study contacts
- Study coordinator: Sophie Debrock, PhD
- Email: sophie.debrock@uzleuven.be
- Phone: 0032016340812
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.