Using hyaluronan-enriched medium to improve pregnancy rates
Official title: Effect of Hyaluronan-enriched Medium on the Cumulative Ongoing Pregnancy Rate: a Prospective Randomized Trial
Run by KU Leuven · NCT04697823 · Data updated 2026-11-12
This study is testing if using a special medium with hyaluronan during egg retrieval can help improve pregnancy rates for patients trying to conceive.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 40 Years |
| Sex | Women only |
| Enrollment | 400 (estimated) |
| Sponsor | KU Leuven Academic / other |
| Locations | 1 site (Leuven) |
| Status | Recruiting |
| Started | January 1, 2021 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | March 30, 2026 |
| Trial ID | NCT04697823 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women under 40 years old who are undergoing a second or third oocyte retrieval without a clinical ongoing pregnancy from previous attempts.
✕Probably not a fit
Patients who are older than 40 years or have a BMI over 32 may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the impact of hyaluronan-enriched transfer medium on the cumulative ongoing pregnancy rate in patients undergoing oocyte retrieval. It involves a randomized controlled approach where patients with their own oocytes or embryos and specific eligibility criteria will be treated with this enriched medium. The goal is to determine if this intervention can enhance pregnancy outcomes compared to standard practices.
Why it matters
Potential benefit: If successful, this could lead to higher pregnancy rates for patients undergoing fertility treatments.
How similar studies have gone: Other studies have shown promising results with similar approaches using enriched media in fertility treatments.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with own oocytes/embryos; * Patients with female age at 1st OR in the study \<40 year; * Patients planned for a 2nd oocyte retrieval, with no clinical ongoing pregnancy after the previous oocyte retrieval * Patients planned for a 3rd oocyte retrieval with no clinical ongoing pregnancy after previous oocyte retrievals * Patients with female age at 1st OR in the study \<40 year; * Patients with BMI ≤32; * Patients with written informed consent; Exclusion Criteria: \-
Where it's running
-
Leuven University Fertility Center
Leuven, Belgium Recruiting
Study contacts
- Study coordinator: Sophie Debrock, PhD
- Email: sophie.debrock@uzleuven.be
- Phone: 0032016340812
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.