Clinical trial Recruiting at 1 site Interventional Ages 18 to 40 Women only

Using hyaluronan-enriched medium to improve pregnancy rates

Official title: Effect of Hyaluronan-enriched Medium on the Cumulative Ongoing Pregnancy Rate: a Prospective Randomized Trial

Run by KU Leuven · NCT04697823 · Data updated 2026-11-12

This study is testing if using a special medium with hyaluronan during egg retrieval can help improve pregnancy rates for patients trying to conceive.

Quick facts

Study typeInterventional
Ages18 Years to 40 Years
SexWomen only
Enrollment400 (estimated)
SponsorKU Leuven
Academic / other
Locations1 site (Leuven)
StatusRecruiting
StartedJanuary 1, 2021
Main results expectedDecember 31, 2026
Study endsDecember 31, 2026
Registry record updatedMarch 30, 2026
Trial IDNCT04697823 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are women under 40 years old who are undergoing a second or third oocyte retrieval without a clinical ongoing pregnancy from previous attempts.

Probably not a fit

Patients who are older than 40 years or have a BMI over 32 may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the impact of hyaluronan-enriched transfer medium on the cumulative ongoing pregnancy rate in patients undergoing oocyte retrieval. It involves a randomized controlled approach where patients with their own oocytes or embryos and specific eligibility criteria will be treated with this enriched medium. The goal is to determine if this intervention can enhance pregnancy outcomes compared to standard practices.

Why it matters

Potential benefit: If successful, this could lead to higher pregnancy rates for patients undergoing fertility treatments.

How similar studies have gone: Other studies have shown promising results with similar approaches using enriched media in fertility treatments.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients with own oocytes/embryos;
* Patients with female age at 1st OR in the study \<40 year;
* Patients planned for a 2nd oocyte retrieval, with no clinical ongoing pregnancy after the previous oocyte retrieval
* Patients planned for a 3rd oocyte retrieval with no clinical ongoing pregnancy after previous oocyte retrievals
* Patients with female age at 1st OR in the study \<40 year;
* Patients with BMI ≤32;
* Patients with written informed consent;

Exclusion Criteria:

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Where it's running

  • Leuven University Fertility Center
    Leuven, Belgium
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.