Using Hexadecanal to enhance therapy for PTSD
Official title: Testing Potential Enhancement of Standard Cognitive Processing Therapy for PTSD Using Hexadecanal: A Randomized Controlled Trial
Run by Tel Aviv University · NCT06968312 · Data updated 2026-11-12
This study is testing if adding a special odor called Hexadecanal to therapy can help people with PTSD feel better compared to just the therapy alone.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | Tel Aviv University Academic / other |
| Locations | 1 site (Tel Aviv) |
| Status | Recruiting |
| Started | May 5, 2025 |
| Main results expected | September 30, 2026 |
| Study ends | December 30, 2026 |
| Registry record updated | May 16, 2025 |
| Trial ID | NCT06968312 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and over diagnosed with PTSD according to DSM-5 criteria.
✕Probably not a fit
Patients with bipolar disorder, psychosis, neurological disorders, or those undergoing parallel psychotherapy may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the effectiveness of adding Hexadecanal, an odor molecule, to Cognitive Processing Therapy (CPT) for patients with Post Traumatic Stress Disorder (PTSD). In a triple-blind randomized controlled trial, 40 participants will receive either Hexadecanal or a placebo during therapy sessions to assess changes in PTSD symptom severity. The study aims to determine if the presence of Hexadecanal can improve psychological well-being and therapeutic outcomes compared to standard CPT alone.
Why it matters
Potential benefit: If successful, this approach could enhance the effectiveness of existing PTSD treatments, leading to better patient outcomes.
How similar studies have gone: While the use of odor molecules in therapy is a novel approach, similar studies exploring sensory enhancements in psychological treatments have shown promising results.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of PTSD according to DSM-5 * Age 18 years and over * Eligible for CPT treatment at the National Center for Traumatic Stress and Resilience Exclusion Criteria: * Bipolar disorder, psychosis, neurological disorders * Drug Addiction * Parallel psychotherapy * Congenital or acquired anosmia.
Where it's running
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Tel Aviv University
Tel Aviv, Israel Recruiting
Study contacts
- Principal investigator: Yair Bar Haim, PhD — Tel Aviv University
- Study coordinator: Yair Bar Haim, PhD
- Email: yair1@tauex.tau.ac.il
- Phone: 03-6405465
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.