Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Using Hexadecanal to enhance therapy for PTSD

Official title: Testing Potential Enhancement of Standard Cognitive Processing Therapy for PTSD Using Hexadecanal: A Randomized Controlled Trial

Run by Tel Aviv University · NCT06968312 · Data updated 2026-11-12

This study is testing if adding a special odor called Hexadecanal to therapy can help people with PTSD feel better compared to just the therapy alone.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment40 (estimated)
SponsorTel Aviv University
Academic / other
Locations1 site (Tel Aviv)
StatusRecruiting
StartedMay 5, 2025
Main results expectedSeptember 30, 2026
Study endsDecember 30, 2026
Registry record updatedMay 16, 2025
Trial IDNCT06968312 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18 and over diagnosed with PTSD according to DSM-5 criteria.

Probably not a fit

Patients with bipolar disorder, psychosis, neurological disorders, or those undergoing parallel psychotherapy may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of adding Hexadecanal, an odor molecule, to Cognitive Processing Therapy (CPT) for patients with Post Traumatic Stress Disorder (PTSD). In a triple-blind randomized controlled trial, 40 participants will receive either Hexadecanal or a placebo during therapy sessions to assess changes in PTSD symptom severity. The study aims to determine if the presence of Hexadecanal can improve psychological well-being and therapeutic outcomes compared to standard CPT alone.

Why it matters

Potential benefit: If successful, this approach could enhance the effectiveness of existing PTSD treatments, leading to better patient outcomes.

How similar studies have gone: While the use of odor molecules in therapy is a novel approach, similar studies exploring sensory enhancements in psychological treatments have shown promising results.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Diagnosis of PTSD according to DSM-5
* Age 18 years and over
* Eligible for CPT treatment at the National Center for Traumatic Stress and Resilience

Exclusion Criteria:

* Bipolar disorder, psychosis, neurological disorders
* Drug Addiction
* Parallel psychotherapy
* Congenital or acquired anosmia.

Where it's running

  • Tel Aviv University
    Tel Aviv, Israel
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.