Using furosemide to predict kidney transplant success
Furosemide Stress Test as a Marker of Postoperative Kidney Allograft Function
This study tests if a furosemide stress test can help predict how well a kidney transplant will work in patients receiving kidneys from deceased donors.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 180 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | King Chulalongkorn Memorial Hospital Academic / other |
| Locations | 1 site (Bangkok) |
| Trial ID | NCT03071536 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of a furosemide stress test in predicting early graft function in patients undergoing kidney transplantation. By administering a standardized dose of furosemide post-surgery, researchers aim to measure urine output as a potential biomarker for graft function. The study focuses on patients receiving deceased donor kidneys at King Chulalongkorn Memorial Hospital. The goal is to improve postoperative care and outcomes for kidney transplant recipients.
Who should consider this trial
Good fit: Ideal candidates are patients receiving a deceased donor kidney transplant at King Chulalongkorn Memorial Hospital who can provide informed consent.
Not a fit: Patients with known allergies to furosemide or those requiring urgent dialysis due to surgical complications will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to better prediction of kidney transplant success and improved patient management.
How similar studies have performed: There is no prior study directly evaluating the urine response to furosemide in this context, making this approach novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Deceased donor kidney transplantation at KCMH * informed consent is accepted Exclusion Criteria: * Known allergy to furosemide * Surgical complication of allograft * Urgently needed for dialysis (refractory hypervolemia, uremic symptoms, and hyperkalemia)
Where this trial is running
Bangkok
- King Chulalongkorn Memorial Hospital — Bangkok, Thailand (Recruiting)
Study contacts
- Principal investigator: suwasin udomkarnjananun, M.D. — King Chulalongkorn Memorial Hospital and Chulalongkorn University
- Study coordinator: Suwasin udomkarnjananun, M.D.
- Email: suwasin.u@gmail.com
- Phone: 66899679885
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.