Using extracellular vesicles in fibrin gel to repair cartilage

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project aims to create and analyze a fibrin gel derived from platelet-rich plasma (PRP) that is loaded with extracellular vesicles from mesenchymal stromal cells (MSC). The goal is to combine the beneficial effects of PRP growth factors with the cartilage-stimulating properties of MSC-EVs to enhance cartilage repair. This innovative approach seeks to provide orthopedic patients with a more effective treatment option that can be easily integrated into standard clinical practices.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* males and females ≥ 18
* patients undergoing plastic surgery procedures;
* patients undergoing elective joint surgery with a diagnosis of knee or hip osteoarthritis (any Kellgren-Lawrence grade);
* patients undergoing regenerative medicine treatments with PRP with a diagnosis of knee or hip osteoarthritis (any Kellgren-Lawrence grade;
* signed Informed Consent for the study

Exclusion Criteria:

* Positive virological test (HIV, HCV, HBV, TPHA)
* Pregnancy or breastfeeding by self-declaration
* Other conditions that, at the discretion of the investigator or the physician

Where it's running

• I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
  Milan, Mi, Italy Recruiting

Study contacts

• Study coordinator: Giuseppe Peretti
• Email: enrico.ragni@grupposandonato.it
• Phone: +390283502254

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.