Using electrical impedance tomography to find the best breathing support for newborns

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify the optimal level of positive end-expiratory pressure (PEEP) for newborn infants requiring respiratory support. By utilizing electrical impedance tomography (EIT), forced oscillation technique (FOT), and saturation oxygenation pressure index (SOPI), the study seeks to provide a non-invasive assessment of lung ventilation and mechanics. The goal is to minimize ventilator-induced lung injury and improve long-term respiratory outcomes for these infants. The study will be conducted at the University Children's Hospital Basel, focusing on infants with specific gestational ages and mechanical ventilation needs.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 22+0 to 41+6 weeks' gestational age
* Requiring mechanical ventilation
* Written informed parental consent

Exclusion Criteria:

* Major congenital malformations including lung and cardiac malformations
* Infants on high frequency oscillatory ventilation
* Lack of written informed parental consent

Where it's running

• Department of Neonatology, University Children's Hospital Basel UKBB
  Basel, Switzerland Recruiting

Study contacts

• Principal investigator: Roland Gerull, Dr. med. — Department of Neonatology, University Children's Hospital Basel UKBB
• Study coordinator: Roland Gerull, Dr. med.
• Email: Roland.Gerull@ukbb.ch
• Phone: +41 61 70 42 307

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Risks of lung-opening maneuvers and PEEP adjustments in ventilated children

  This project will track how often lung-opening maneuvers and PEEP adjustments cause complications in children under 14 who are on mechanical ventilation in the PICU.

  Recruiting Hospital de Alta Complejidad en Red · Canuelas, Buenos Aires · NCT07233304

• Personalized lung volume optimization with PEEP titration for children after heart surgery or with severe respiratory failure

  This trial tests whether a personalized lung volume optimization maneuver using PEEP titration can improve heart and lung function in children after cardiopulmonary bypass surgery or in those with severe respiratory failure at risk for ECMO.

  Recruiting Phase 1/2 Charite University, Berlin, Germany · Tübingen · NCT07193719

• Using Positive End-Expiratory Pressure during CPR for Cardiac Arrest

  This study is testing if using a special breathing technique during CPR can help adults who have a cardiac arrest outside of the hospital survive better and have good brain function afterwards.

  Recruiting at 6 sites Phase 3 University Hospital, Ghent · Ostend, West-Flandres and 6 other locations · NCT06939335

• Using PEEP and EIT to keep lungs open in babies born before 32 weeks

  This study tests whether adjusting gentle breathing pressure (PEEP) guided by electrical impedance tomography (EIT) helps keep the lungs open in babies born before 32 weeks who need CPAP or ventilator support.

  Recruiting South Tees Hospitals NHS Foundation Trust · Middlesbrough · NCT06705257

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.