Using EEG to guide anesthesia in major abdominal surgery
Official title: Impact of Reduced Intraoperative Norepinephrine Requirements Via Processed Electroencephalography-Guided General Anesthesia on Patient Outcomes After Major Abdominal Surgeries
Run by Assiut University · NCT06753409 · Data updated 2026-11-12
This study is testing if using brain wave monitoring during anesthesia can help reduce low blood pressure and complications after major abdominal surgery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 70 Years |
| Sex | All |
| Enrollment | 162 (estimated) |
| Sponsor | Assiut University Academic / other |
| Locations | 1 site (Asyut) |
| Status | Recruiting |
| Started | February 1, 2025 |
| Main results expected | December 1, 2026 |
| Study ends | January 1, 2027 |
| Registry record updated | October 28, 2026 |
| Trial ID | NCT06753409 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients aged 18-70 scheduled for major abdominal surgery lasting more than 2 hours with an ASA score of I-III.
✕Probably not a fit
Patients with uncontrolled hypertension, chronic kidney disease, or those undergoing emergency surgeries may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the impact of processed electroencephalography (pEEG)-guided general anesthesia on reducing the need for norepinephrine during major abdominal surgeries. By minimizing intraoperative hypotension (IOH) through tailored anesthesia, the study aims to decrease postoperative complications, particularly acute kidney injury (AKI). Participants will be randomly assigned to receive either pEEG-guided or non-pEEG-guided anesthesia, with outcomes assessed post-surgery. The research addresses a critical gap in managing IOH and its associated risks in surgical patients.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the incidence of postoperative acute kidney injury in patients undergoing major abdominal surgery.
How similar studies have gone: While the use of pEEG in anesthesia is gaining interest, this specific approach to managing IOH in major abdominal surgery is relatively novel and has not been extensively tested in prior studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients scheduled for major abdominal surgery lasting more than 2 hours under general anesthesia. 2. American Society of Anesthesiologists Physical Status (ASA) score I-III. 3. Age range of 18-70 years. 4. Both male and female patients. Exclusion Criteria: 1. Emergency surgeries. 2. Uncontrolled hypertension (systolic blood pressure \>150 mm Hg) despite medication. 3. Recent acute cardiovascular events, including heart failure or acute coronary syndrome. 4. Chronic kidney disease with a glomerular filtration rate \<30 ml/min/1.73 m² or requiring renal replacement therapy. 5. Severe hepatic failure (ASAT/ALAT \>2N, elevated bilirubin, or PT \<50%). 6. Preoperative sepsis or septic shock. 7. Pregnancy. 8. Patient refusal to participate in the study.
Where it's running
-
Assiut University Hospitals
Asyut, Egypt Recruiting
Study contacts
- Study coordinator: Walaa H Mohamed, Assistant Lecturer
- Email: walaa95.hamdy@gmail.com
- Phone: +201061403338
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.