Using EEG to guide anesthesia in major abdominal surgery

Impact of Reduced Intraoperative Norepinephrine Requirements Via Processed Electroencephalography-Guided General Anesthesia on Patient Outcomes After Major Abdominal Surgeries

This study is testing if using brain wave monitoring during anesthesia can help reduce low blood pressure and complications after major abdominal surgery.

Quick facts

• Phase: NA
• Study type: Interventional
• Enrollment: 162 (estimated)
• Ages: 18 Years to 70 Years
• Sex: All
• Sponsor: Assiut University (other)
• Locations: 1 site (Asyut)
• Trial ID: NCT06753409 on ClinicalTrials.gov

What this trial studies

This study evaluates the impact of processed electroencephalography (pEEG)-guided general anesthesia on reducing the need for norepinephrine during major abdominal surgeries. By minimizing intraoperative hypotension (IOH) through tailored anesthesia, the study aims to decrease postoperative complications, particularly acute kidney injury (AKI). Participants will be randomly assigned to receive either pEEG-guided or non-pEEG-guided anesthesia, with outcomes assessed post-surgery. The research addresses a critical gap in managing IOH and its associated risks in surgical patients.

Who should consider this trial

Good fit: Ideal candidates are patients aged 18-70 scheduled for major abdominal surgery lasting more than 2 hours with an ASA score of I-III.

Not a fit: Patients with uncontrolled hypertension, chronic kidney disease, or those undergoing emergency surgeries may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could significantly reduce the incidence of postoperative acute kidney injury in patients undergoing major abdominal surgery.

How similar studies have performed: While the use of pEEG in anesthesia is gaining interest, this specific approach to managing IOH in major abdominal surgery is relatively novel and has not been extensively tested in prior studies.

Eligibility criteria

Inclusion Criteria:

1. Patients scheduled for major abdominal surgery lasting more than 2 hours under general anesthesia.
2. American Society of Anesthesiologists Physical Status (ASA) score I-III.
3. Age range of 18-70 years.
4. Both male and female patients.

Exclusion Criteria:

1. Emergency surgeries.
2. Uncontrolled hypertension (systolic blood pressure \>150 mm Hg) despite medication.
3. Recent acute cardiovascular events, including heart failure or acute coronary syndrome.
4. Chronic kidney disease with a glomerular filtration rate \<30 ml/min/1.73 m² or requiring renal replacement therapy.
5. Severe hepatic failure (ASAT/ALAT \>2N, elevated bilirubin, or PT \<50%).
6. Preoperative sepsis or septic shock.
7. Pregnancy.
8. Patient refusal to participate in the study.

Where this trial is running

Asyut

• Assiut University Hospitals — Asyut, Egypt (RECRUITING)

Study contacts

• Study coordinator: Walaa H Mohamed, Assistant Lecturer

Conditions: Postoperative Acute Kidney Injury, Hypotension, Abdominal surgery, Norepinephrine, Acute kidney injury