Using echocardiography to evaluate heart and kidney function in patients with cirrhosis and fluid retention
Point-of-Care Echocardiography to Assess Impact of Dynamic Cardiac Function, Renal and Cardiac Biomarkers in Cirrhosis With Refractory Ascites
PGIMER · NCT05700708
This study is testing how heart and kidney function are connected in patients with cirrhosis and fluid buildup to help improve their care.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 80 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | PGIMER (unknown) |
| Locations | 1 site (Chandigarh, Delhi) |
| Trial ID | NCT05700708 on ClinicalTrials.gov |
What this trial studies
This observational study utilizes point-of-care echocardiography (POC-Echo) to assess cardiac function and volume status in patients suffering from cirrhosis and refractory ascites. It aims to evaluate left ventricular systolic and diastolic dysfunction, inferior vena cava dynamics, and urinary biomarkers in this patient population. The study focuses on understanding the interplay between cardiac function and renal biomarkers in the context of advanced liver disease. By identifying these dynamics, the research seeks to improve patient management and outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are patients diagnosed with cirrhosis of any etiology who are experiencing refractory ascites.
Not a fit: Patients with hepatocellular carcinoma, active variceal bleeding, or significant cardiac conditions such as coronary artery disease may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the understanding of cardiac and renal interactions in cirrhosis, leading to better management strategies for affected patients.
How similar studies have performed: While the use of echocardiography in liver disease is established, this specific approach focusing on dynamic cardiac function in cirrhosis with refractory ascites is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Cirrhosis of any Etiology * Patient with Refractory Ascites Exclusion Criteria: * Hepatocellular carcinoma * Patients with active variceal bleeding * HIV or severe immunocompromised state * Chronic kidney disease (CKD) on renal replacement therapy (RRT), * Previous transjugular intra hepatic portosystemic shunt (TIPS) * Porto-pulmonary hypertension, * Coronary artery disease * Congenital or valvular heart disease * Prosthetic cardiac valves
Where this trial is running
Chandigarh, Delhi
- PGIMER — Chandigarh, Delhi, India (RECRUITING)
Study contacts
- Study coordinator: Madhumita Premkumar
- Email: drmadhumitap@gmail.com
- Phone: 01722754777
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Cirrhosis, Liver, Acute-On-Chronic Liver Failure, Refractory Ascites, Ascites, Acute Kidney Injury, Cirrhotic Cardiomyopathy, Acute kidney injury