Using dexmedetomidine and dexamethasone to improve pain management in upper limb surgery
Comparison of the Anesthetic Effects of Dexmedetomidine and Dexamethasone Added as Adjuvant to Ultrasonography-Guided Infraclavicular Brachial Plexus Block in Upper Limb Surgery
Umraniye Education and Research Hospital · NCT06779604
This study is testing whether adding two medications, dexmedetomidine and dexamethasone, to a nerve block can help people having upper limb surgery manage their pain better after the operation.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 44 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Umraniye Education and Research Hospital (other gov) |
| Locations | 1 site (Istanbul, Umraniye) |
| Trial ID | NCT06779604 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of adding dexmedetomidine and dexamethasone to an infraclavicular brachial plexus block for patients undergoing upper extremity surgery. The focus is on evaluating the onset time, total duration of the block, and the time until the first analgesic is needed. The infraclavicular block is preferred for its effectiveness in providing anesthesia and analgesia while minimizing risks associated with other approaches. The study aims to enhance postoperative pain management through this combined approach.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-70 years with ASA physical status I-II undergoing upper extremity surgery.
Not a fit: Patients with significant comorbidities, prior nerve injuries, or those outside the age range may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved pain control and reduced need for additional analgesics after upper limb surgery.
How similar studies have performed: Other studies have shown promising results with similar adjuvant approaches in nerve blocks, suggesting potential for success in this study.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18-70 years * ASA I-II Exclusion Criteria: * Under 18 years of age and older than 70 years of age, * presence of brachial plexus injury, * patients with bleeding diathesis, * presence of allergy, -contralateral diaphragmatic paralysis, - * presence of nerve injury secondary to trauma, * pre-existing neuropathy of the surgical extremity, * presence of severe pulmonary, * renal and hepatic disease, * congestive heart failure (NYHA stage 3-4), * uncontrolled diabetes mellitus, * history of neuromuscular disease, * patients with extreme obesity or malnutrition (BMI \> 30 kg-1m2 or BMI \<20 kg-1m2), * presence of epilepsy, * history of peripheral vascular disease, * history of chronic pain or fibromyalgia, * pregnant and lactating patients, * patients with local infection at the injection site, * patients undergoing general anesthesia due to inadequacy of the block, * patients refusing to give informed consent, * history of recreational substance use, and chronic narcotic-based painkillers
Where this trial is running
Istanbul, Umraniye
- Umraniye Education and Research Hospital — Istanbul, Umraniye, Turkey (Türkiye) (RECRUITING)
Study contacts
- Study coordinator: ZELİHA TUNCEL, ASC PROF
- Email: zelihalara@yahoo.com
- Phone: 5053577483
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Post Operative Pain, Anesthesia, Acute Pain, infraclavicular nerve block, dexmetomidine, dexamethosone