Clinical trial Recruiting at 1 site Interventional Ages 18 to 60

Using compression garments to help manage POTS symptoms

Official title: Compression Garments in the Community With POTS

Run by University of Calgary · NCT04881318 · Data updated 2026-11-12

This study tests if wearing waist-high and abdominal compression garments can help adults with POTS feel better and manage their symptoms in everyday life.

Quick facts

Study typeInterventional
Ages18 Years to 60 Years
SexAll
Enrollment30 (estimated)
SponsorUniversity of Calgary
Academic / other
Locations1 site (Calgary, Alberta)
StatusRecruiting
StartedMay 17, 2021
Main results expectedDecember 31, 2026
Study endsDecember 31, 2026
Registry record updatedMay 7, 2026
Trial IDNCT04881318 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include adults diagnosed with POTS who reside in Canada and own waist-high compression garments.

Probably not a fit

Patients with overt causes for postural tachycardia or severe anxiety symptoms may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of commercially available waist-high and abdominal compression garments in adults diagnosed with Postural Orthostatic Tachycardia Syndrome (POTS) in a community setting. Participants will wear these garments in their daily lives to assess improvements in heart rate and symptom reduction. The study builds on previous laboratory findings that indicated potential benefits of compression garments for POTS patients. An optional sub-study will also explore the effectiveness of abdominal compression garments.

Why it matters

Potential benefit: If successful, this study could provide a non-pharmacological treatment option that significantly improves the quality of life for POTS patients.

How similar studies have gone: Previous studies have shown promise for compression garments in acute settings, but this approach in a community setting is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Physician diagnosis of Postural Tachycardia Syndrome (POTS)
* Resident of Canada
* Owns waist-high compression garment: medical grade or commercially available tights with a pressure rating provided (e.g. 15-18 mmHg, 20-30 mmHg, 30-40 mmHg)
* Optional Sub-Study: owns an abdominal compression garment (e.g. abdominal shapewear, waist high shorts)
* Able to participate in a 4-day study (2x2 day segments with a 5-day washout period)

Exclusion Criteria:

* Overt cause for postural tachycardia (i.e., acute dehydration, thyroid disease) that precludes POTS diagnosis
* Not a resident of Canada
* Participants with somatization or severe anxiety symptoms will be excluded
* Pregnant (self-reported)
* Inability to tolerate compression garments for the duration of the study
* Does not own a waist-high compression garment
* Other factors which in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during previous studies

Where it's running

  • University of Calgary
    Calgary, Alberta, Canada
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.