Testing IV saline for cognitive function in POTS and Long COVID patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of intravenous (IV) saline on cognitive dysfunction in patients diagnosed with Postural Orthostatic Tachycardia Syndrome (POTS) and Post-Acute Sequelae of COVID (Long COVID). Participants will receive either a 999 mL infusion of normal saline or a placebo of 50 mL saline to assess improvements in cognitive function, specifically targeting symptoms like brain fog and mental fatigue. The study aims to provide initial insights into the neurocognitive impairments associated with these conditions and evaluate the potential therapeutic role of saline infusions. By comparing cognitive performance before and after treatment, the researchers hope to establish a foundation for future studies on underlying mechanisms and treatments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with diagnosis of Long COVID
* SARS-COV2 test positive
* Symptoms \> 12 weeks post COVID
* Subjective complaint of 'brain fog" or cognitive dysfunction
* Patients with diagnosis of Postural Orthostatic Syndrome (POTS) from the Calgary Autonomic Investigation and Management Clinic
* Subjective complaint of 'brain fog" or cognitive impairment
* Healthy participants
* Without POTS or "brain fog"
* Age 18 to 60 years
* Female and Male
* Able to give an informed consent

Exclusion Criteria:

* Patients with overt causes for POTS (e.g., dehydration, prolonged bed rest)
* An inability to safely withdraw from medicine(s) that could make test interpretation difficult and impossible.
* Other factors which are in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during previous studies or an unpredictable schedule.
* Unable to give an informed consent.

Where it's running

• University of Calgary
  Calgary, Alberta, Canada Recruiting

Study contacts

• Principal investigator: Satish R Raj, MD MSCI — University of Calgary
• Study coordinator: Satish R Raj, MD MSCI
• Email: autonomic.research@ucalgary.ca
• Phone: (403)210-6152

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• A study using wearable devices to manage Long COVID symptoms

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• Improving blood pressure control in children who faint

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.