Using cold saline to prevent heart damage after a heart attack

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the use of intracoronary hypothermia as a method to prevent reperfusion injury in patients experiencing ST-elevation myocardial infarction (STEMI). It aims to determine the safety and effectiveness of administering cold saline during percutaneous coronary intervention, a common treatment for restoring blood flow in blocked arteries. Patients will be randomly assigned to receive either the hypothermia treatment or standard revascularization. The study will enroll 60 participants and has received ethical approval.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Acute ST-elevation myocardial infarction
* Time from onset of symptoms less than 12 hours
* Given informed consent

Exclusion Criteria:

* Contraindication to MRI
* Cardiogenic shock
* Conduction disturbance: Atrioventricular block: 2nd and 3rd degree. SA block.
* Sick sinus syndrome requiring implantable pacemaker
* Pulmonary edema
* Active inflammatory condition
* Active chemo/radiation therapy

Where it's running

• Cardiology Research Institute, Tomsk National Research Medical Center
  Tomsk, Russia Recruiting

Study contacts

• Principal investigator: Christina Nasekina — Cardiology Research Institute, Tomsk National Research Medical Center
• Study coordinator: Christina Nasekina
• Email: christina.nasekina@mail.ru
• Phone: 7-983-239-63-70

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Preventing reperfusion injury during ST-elevation heart attack using Xolatryp

  This will test whether a single 6-hour IV infusion of Xolatryp given during primary PCI helps people having their first ST-elevation heart attack reduce heart muscle damage and improve short-term heart function.

  Recruiting at 5 sites Phase 2 Nyrada Pty Ltd · Kingswood, New South Wales and 7 other locations · NCT07362446

• Heart@Home: Safe, at-home care for people with acute heart problems compared with hospital care

  This trial tests whether hospital-level care at home can safely and effectively treat adults with acute heart conditions who would normally be in the hospital.

  Recruiting Tel-Aviv Sourasky Medical Center · Tel Aviv · NCT07913152

• Reducing slow-flow and no-reflow during STEMI with a high-dose intracoronary adenosine protocol

  In STEMI patients undergoing primary PCI, this trial tests whether giving a high-dose intracoronary adenosine before balloon or stent inflation can prevent slow-flow or no-reflow.

  Recruiting at 2 sites Punjab Institute of Cardology · Lahore, Punjab Province and 1 other locations · NCT07898696

• Digital cardiac rehab to help heart attack patients improve function

  A digital health–supported cardiac rehabilitation program is being tested to see if it helps people after a heart attack improve fitness and stay engaged with rehab, compared with standard outpatient rehab.

  Recruiting Cairo University · Minya, Minya Province · NCT07867197

• NMR-based Risk Test and Digital Health Support for midlife adults in Eloisa

  This study tests whether an NMR metabolomics risk test can guide tailored digital health programs for midlife adults at risk of diabetes, heart disease, stroke, kidney disease, or fatty liver.

  Recruiting University of Eastern Finland · Savonlinna · NCT07820800

• Drug-coated balloons vs drug-eluting stents for immediate slow-flow/no-reflow in STEMI with high thrombus

  This study tests whether using a drug-coated balloon instead of a drug-eluting stent during PCI helps reduce immediate slow-flow or no-reflow in STEMI patients with high thrombus burden.

  Recruiting Xijing Hospital · Xi'an, Shaanxi · NCT07806370

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.