Using carbon dioxide to reduce brain injuries after aortic dissection surgery
CARbon Dioxide Flooding to Reduce Postoperative Neurological Injury Following Surgery for Acute Type A Aortic Dissection - A Prospective, Randomized, Blinded, Controlled Clinical Trial
This study is testing if using carbon dioxide during surgery for aortic dissection can help prevent brain injuries after the operation.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Region Skane Academic / other |
| Locations | 1 site (Lund) |
| Trial ID | NCT04962646 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the use of carbon dioxide flooding during surgery for acute type A aortic dissection to reduce the risk of postoperative neurological injuries. Aortic dissection is a critical condition that can lead to severe complications, including stroke. The study aims to determine if carbon dioxide, which is more soluble in blood than air, can effectively displace air from the surgical site and minimize neurological damage. Patients undergoing surgery for this condition will be monitored for neurological outcomes postoperatively.
Who should consider this trial
Good fit: Ideal candidates for this study are patients diagnosed with acute type A aortic dissection who are scheduled for surgical repair.
Not a fit: Patients with new-onset neurological symptoms or a history of stroke with permanent neurological deficiency may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the incidence of neurological injuries and improve recovery outcomes for patients undergoing surgery for aortic dissection.
How similar studies have performed: While the use of carbon dioxide flooding in cardiac procedures has been explored, this specific application for aortic dissection surgery is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Verified acute type A aortic dissection. * Patient accepted for surgical repair. Exclusion Criteria: * New-onset neurological symptoms defined as focal neurological symptoms or altered state of consciousness at time of inclusion. * History of stroke with permanent neurological deficiency. * Previous cardiac surgery. * Surgery performed with cross clamping of the aorta without open distal anastomosis or open inspection of the distal aorta. * Presence of implants or devices not compatible with Magnetic Resonance Imaging.
Where this trial is running
Lund
- Skane University Hospital — Lund, Sweden (Recruiting)
Study contacts
- Principal investigator: Igor Zindovic, MD. PhD — Region Skåne, Skåne university hospital
- Study coordinator: Igor Zindovic, MD, PhD
- Email: igor.zindovic@med.lu.se
- Phone: +4646175288
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.