Using carbon dioxide to reduce brain injuries after aortic dissection surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the use of carbon dioxide flooding during surgery for acute type A aortic dissection to reduce the risk of postoperative neurological injuries. Aortic dissection is a critical condition that can lead to severe complications, including stroke. The study aims to determine if carbon dioxide, which is more soluble in blood than air, can effectively displace air from the surgical site and minimize neurological damage. Patients undergoing surgery for this condition will be monitored for neurological outcomes postoperatively.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Verified acute type A aortic dissection.
* Patient accepted for surgical repair.

Exclusion Criteria:

* New-onset neurological symptoms defined as focal neurological symptoms or altered state of consciousness at time of inclusion.
* History of stroke with permanent neurological deficiency.
* Previous cardiac surgery.
* Surgery performed with cross clamping of the aorta without open distal anastomosis or open inspection of the distal aorta.
* Presence of implants or devices not compatible with Magnetic Resonance Imaging.

Where it's running

• Skane University Hospital
  Lund, Sweden Recruiting

Study contacts

• Principal investigator: Igor Zindovic, MD. PhD — Region Skåne, Skåne university hospital
• Study coordinator: Igor Zindovic, MD, PhD
• Email: igor.zindovic@med.lu.se
• Phone: +4646175288

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.