Using brain-computer interface neurofeedback to improve stroke rehabilitation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to compare the effectiveness of closed-loop brain-computer interface (BCI) driven observational imitation training against sham BCI open-loop training in enhancing upper limb motor functions in stroke patients. The study will involve 44 participants who will engage in kinesthetic motor imagery, with the closed-loop group receiving real-time feedback based on their brain activity, while the sham group will receive feedback based on another participant's activity. The trial will measure improvements in motor function and mirror neuron activation using functional near-infrared spectroscopy (fNIRS) and electroencephalography (EEG). Participants will undergo ten training sessions to assess the outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria

1. unilateral upper extremity motor deficits caused by ischemic stroke, confirmed by medical documents such as discharge summary and/or neuroimaging examinations.
2. chronic phase of stroke, i.e., time after stroke onset more than six months.
3. aged between 18 and 75 years old.
4. with mildly-to-moderately impaired upper limb functional activity that is stratified according to the levels 3-7 in the Functional Test for the Hemiplegic Upper Extremity.
5. able to give informed written consent to participate in the study.
6. able to read and understand traditional Chinese.

Exclusion Criteria

1. previous diagnosis of any neurological disease excluding ischemic stroke.
2. presence of any sign of cognitive problems (The Montreal cognitive assessment Hong Kong version\<22/30).
3. Severe spasticity measured by the Modified Ashworth Scale score\>2 in the hand, wrist or elbow extensor muscle in the hemiparetic upper extremity.
4. with other notable impairments of the upper limb not caused by stroke (e.g., bone fracture in the past year, congenital deformity, or other impairments).
5. current participation in any other treatment programme or clinical study involving exercise, non-invasive brain stimulation, or BCI/neurofeedback.

Where it's running

• Jack Jiaqi Zhang
  Hong Kong, Hong Kong, Hong Kong Recruiting

Study contacts

• Study coordinator: Jack Jiaqi Zhang, PhD
• Email: jack-jiaqi.zhang@polyu.edu.hk
• Phone: 27666696

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.