Using brain activity patterns to improve hand recovery after stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the use of transcranial magnetic stimulation (TMS) to enhance recovery of hand motor function in stroke patients by targeting specific brain activity patterns. Researchers have developed a machine learning framework that identifies personalized brain states associated with strong corticospinal tract (CST) activation. Participants will undergo two days of testing to evaluate their brain activity and the integrity of their CST pathways. The goal is to optimize TMS delivery to maximize its effectiveness in promoting motor recovery.

Why it matters

Who can join: the full rules

* Presence of residual upper extremity hemiparesis, defined as any of the following Fugl Meyer Upper Extremity Score \<66 Wolf Motor Function Test Score \<70 Affected hand performance on the 9-Hole Peg Test \>= 10% worse than unaffected hand Affected hand pinch, key, or power grip performance \>= 10% worse than unaffected hand
* Occurrence of ischemic or hemorrhagic stroke \>= 6 months before participation
* Willingness and ability to provide informed consent
* No history of neurological disease and/or neurological injury other than stroke
* No TMS contraindications, including but not limited to:

Cardiac pacemaker Cochlear implant Cortical stimulator Deep brain stimulator Vagus nerve stimulator Cervical spine epidural stimulation Ventriculoperitoneal shunt Ferromagnetic metallic implants above the level of the seventh cervical vertebra Seizure in the last 12 months while taking anti-epilepsy medication History of adverse reactions to TMS or peripheral nerve stimulation Current, suspected, or planned pregnancy Any recent changes (within the last month) to medication use

\- Presence of residual corticospinal connections innervating an affected upper extremity muscle following stimulation of the lesioned hemisphere (i.e., MEP+), evaluated at rest

Where it's running

• University of Texas at Austin
  Austin, Texas, United States Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.